Department of Ophthalmology, Edith Wolfson Medical Center, Holon, Israel.
Retina. 2012 Jan;32(1):112-9. doi: 10.1097/IAE.0b013e31821ba2c4.
To compare retinal blood flow velocity in small vessels of patients with early diabetes mellitus (DM), without any morphologic changes related to diabetic retinopathy, with that in a control group.
The authors used the retinal function imager to measure blood flow velocities, from many small vessels, simultaneously. Twenty-three eyes of 14 patients with early DM and 51 eyes of 31 healthy subjects were enrolled. Differences between the patients and the control group were assessed by mixed linear models.
Venous average velocity significantly increased in the DM group (3.8 ± 1.2 vs. 2.9 ± 0.5 mm/second, P < 0.0001) than in the healthy subjects. Arterial velocity of DM patients was also significantly higher (4.7 ± 1.7 vs. 4.1 ± 0.9 mm/second, P = 0.03). There was no statistically significant difference between groups in age, gender, heart rate, and systolic blood pressure. The diastolic blood pressure in the DM patients was lower than that in the healthy group (P = 0.03).
There was an increase in arterial and venous retinal blood flow velocities of patients with early DM with no diabetic retinopathy. These findings support the notion that abnormalities in vessel function exist in diabetic eyes before the development of structural changes. This noninvasive approach facilitated the assessment of early hemodynamic abnormalities and may assist in screening and monitoring.
比较早期糖尿病（DM）患者无糖尿病视网膜病变相关形态改变的小血管视网膜血流速度与对照组之间的差异。
作者使用视网膜功能成像仪同时测量多个小血管的血流速度。共纳入 14 例早期 DM 患者的 23 只眼和 31 名健康对照者的 51 只眼。采用混合线性模型评估患者与对照组之间的差异。
DM 组静脉平均速度明显高于健康对照组（3.8 ± 1.2 比 2.9 ± 0.5mm/秒，P < 0.0001）。DM 患者的动脉速度也明显升高（4.7 ± 1.7 比 4.1 ± 0.9mm/秒，P = 0.03）。两组间年龄、性别、心率和收缩压无统计学差异。DM 患者的舒张压低于健康对照组（P = 0.03）。
早期无糖尿病视网膜病变的 DM 患者的视网膜动脉和静脉血流速度均增加。这些发现支持在结构改变发生之前，糖尿病眼中存在血管功能异常的观点。这种非侵入性方法有助于评估早期血流动力学异常，并可能有助于筛查和监测。
