Sano Ayako, Miyaji Makoto, Kamei Katsuhiko, Mikami Yuzuru, Nishimura Kazuko
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
Nihon Ishinkin Gakkai Zasshi. 2006;47(2):113-7. doi: 10.3314/jjmm.47.113.
The Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University is the only organization in Japan to possess a series isolates of Coccidioides spp., which are the most virulent pathogenic fungi and which are treated as biosafety level 3 microorganisms. Recently, the genus Coccidioides has been classified into two species, C. immitis and C. posadasii, based on their endemic areas and genotyping; the former species is endemic to the state of California, and the latter is endemic to other parts of North and South America. We reevaluated 19 isolates of Coccidioides immitis stored in our center using a multiple gene analysis. Five isolates were identified as C. immitis and 14 as C. posadasii. Their sequence information in GenBank will help to identify the two genospecies of Coccidioides spp.
千叶大学致病性真菌与微生物毒素研究中心是日本唯一拥有球孢子菌属系列菌株的机构，球孢子菌属是毒性最强的致病真菌，被视为生物安全3级微生物。最近，基于其流行区域和基因分型，球孢子菌属已被分为两个种，即粗球孢子菌和波萨达斯球孢子菌；前一个种在加利福尼亚州流行，后一个种在南北美洲的其他地区流行。我们使用多基因分析对保存在本中心的19株粗球孢子菌分离株进行了重新评估。5株分离株被鉴定为粗球孢子菌，14株为波萨达斯球孢子菌。它们在GenBank中的序列信息将有助于鉴定球孢子菌属的两个基因种。
