Avila Marcos Pereira de, Freitas André Moraes, Isaac David Leonardo Cruvinel, Bastos André Luis de Moura, Pena Rafael Valadares
Centro Brasileiro de Cirurgia de Olhos, Goiânia (GO), Brazil.
Arq Bras Oftalmol. 2006 Mar-Apr;69(2):255-9. doi: 10.1590/s0004-27492006000200022. Epub 2006 May 8.
Interferon is an immunomodulating cytokine used to treat patients with different diseases, such as hepatitis C chronic infection. Pegylated interferon is a new type of interferon, developed to increase the half-life of the drug. Many side effects have been related to its use, including ocular toxicity and retinopathy. The most reported ocular findings are cotton-wool spots and hemorrhages located at the posterior pole and surrounding optic nerve head. We describe one case of pegylated interferon-associated retinopathy with visual loss. The patient had visual acuity improvement four weeks after discontinuation of the medication and the ocular findings became much more subtle.
干扰素是一种用于治疗不同疾病患者的免疫调节细胞因子，如丙型肝炎慢性感染。聚乙二醇化干扰素是一种新型干扰素，旨在延长药物的半衰期。其使用与许多副作用有关，包括眼部毒性和视网膜病变。最常报告的眼部表现是位于后极和视神经乳头周围的棉絮斑和出血。我们描述了一例聚乙二醇化干扰素相关视网膜病变伴视力丧失的病例。患者在停药四周后视力有所改善，眼部表现也变得更加不明显。
