接受聚乙二醇化干扰素α-2a与利巴韦林联合治疗的慢性丙型肝炎患者视网膜病变的发生率
Incidence of retinopathy in chronic hepatitis C patients treated with pegylated interferon alpha 2a and ribavirin combination therapy.
作者信息
Kashif Muhammad, Saleem Muhammad Khurram, Farooka Imran Khan, Husnain Amina, Siddiqui Arif Mahmood
机构信息
Dr. Muhammad Khurram Saleem, Assistant Professor of Medicine, CMH Lahore Medical College, Combined Military Hospital Lahore, Pakistan.
Dr. Imran Khan Farooka, Senior Registrar Medicine, Medical Unit II, Jinnah Hospital Lahore, Pakistan.
出版信息
Pak J Med Sci. 2015 Jan-Feb;31(1):174-7. doi: 10.12669/pjms.311.6321.
OBJECTIVES
The objective of this study was to determine the incidence of retinopathy in chronic hepatitis C patients treated with Pegylated interferon alpha 2a and Ribavirin.
METHODS
This descriptive case series study was conducted in Medical Unit II of the Jinnah Hospital Lahore from September 2012 to February 2013. One hundred chronic hepatitis C patients visiting Medical Unit II outpatient department fulfilling inclusion criteria were selected for this study via non probability purposive sampling. Patients were started on pegylated interferon and ribavirin combination therapy. Subjects were subjected to dilated eye fundoscopic examination at the start of therapy and then after three months of the therapy.
RESULTS
One hundred patients were included in this study. Out of these 100 patients 5% developed retinopathy whereas fundus examination was normal in rest of the patients.
CONCLUSION
Interferon therapy can lead to retinopathy. Periodic fundoscopic examinations help in early detection and prevent progression to permanent visual loss.
目的
本研究的目的是确定接受聚乙二醇化干扰素α-2a和利巴韦林治疗的慢性丙型肝炎患者视网膜病变的发生率。
方法
本描述性病例系列研究于2012年9月至2013年2月在拉合尔真纳医院第二内科进行。通过非概率目的抽样，选择了100名符合纳入标准且前往第二内科门诊就诊的慢性丙型肝炎患者进行本研究。患者开始接受聚乙二醇化干扰素和利巴韦林联合治疗。在治疗开始时以及治疗三个月后，对受试者进行散瞳眼底镜检查。
结果
本研究纳入了100名患者。在这100名患者中，5%出现了视网膜病变，而其余患者的眼底检查正常。
结论
干扰素治疗可导致视网膜病变。定期眼底镜检查有助于早期发现并防止进展为永久性视力丧失。
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