网格蛋白的细胞功能。
The cellular functions of clathrin.
作者信息
Royle S J
机构信息
MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom.
出版信息
Cell Mol Life Sci. 2006 Aug;63(16):1823-32. doi: 10.1007/s00018-005-5587-0.
Abstract
Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathrin, a three-legged protein that can form lattice-like coats on membranes destined for trafficking. In this review, I outline what we know about clathrin and discuss some recent advances in understanding the basic biology of this fascinating molecule, which include building a molecular model of a clathrin lattice and discovery of a new function for clathrin that occurs during mitosis.
摘要
膜和蛋白质通过小囊泡在细胞内移动。蛋白质衣被有助于此类囊泡从供体膜上出芽。细胞使用的主要衣被类型由网格蛋白组成，网格蛋白是一种三足蛋白，可在用于运输的膜上形成晶格状衣被。在这篇综述中，我概述了我们对网格蛋白的了解，并讨论了在理解这个迷人分子的基础生物学方面的一些最新进展，其中包括构建网格蛋白晶格的分子模型以及发现网格蛋白在有丝分裂期间发挥的新功能。
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