Farkas Zsuzsanna, Szirmai Imre, Kamondi Anita
Department of Neurology, Semmelweis University, Budapest, Hungary.
Mov Disord. 2006 Aug;21(8):1196-9. doi: 10.1002/mds.20934.
It has been suggested that the cerebellum plays a role in the event-based timing of synchronized repetitive movements. We hypothesized that regularity of rhythmic movements in essential tremor (ET) is impaired, since several lines of evidence suggest the involvement of the cerebellum in the pathomechanism of ET. To test this assumption, we examined the regularity and the maximum frequency of auditory paced repetitive movements at slow and fast stimulus rate in 34 ET patients. Variability of rhythmic finger tapping and alternating hand movements, defined by the standard deviation of movement offset before or after the pacing signal, was significantly higher compared to healthy controls. Timing of rhythmic movements of the two hands was disturbed to the same degree. Our results suggest a severe deficit of event-based rhythm generation on both sides in ET, supporting the presumed bilateral cerebellar dysfunction in this disorder.
有人提出，小脑在基于事件的同步重复运动计时中发挥作用。我们假设特发性震颤（ET）中节律性运动的规律性受损，因为有几条证据表明小脑参与了ET的发病机制。为了验证这一假设，我们在34例ET患者中，以慢和快刺激速率检查了听觉驱动的重复运动的规律性和最大频率。与健康对照相比，由起搏信号前后运动偏移的标准差定义的节律性手指敲击和双手交替运动的变异性显著更高。双手节律性运动的计时受到同等程度的干扰。我们的结果表明ET双侧基于事件的节律生成严重不足，支持了该疾病中双侧小脑功能障碍的推测。
