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替硝唑和甲硝唑对艰难梭菌、二路普雷沃菌和脆弱拟杆菌的体外活性。

In vitro activities of tinidazole and metronidazole against Clostridium difficile, Prevotella bivia and Bacteroides fragilis.

作者信息

Citron D M, Tyrrell K L, Warren Y A, Fernandez H, Merriam C V, Goldstein E J C

机构信息

R.M. Alden Research Laboratory, 2001 Santa Monica Blvd., Suite 685W, Santa Monica, CA 90404, USA.

出版信息

Anaerobe. 2005 Dec;11(6):315-7. doi: 10.1016/j.anaerobe.2005.04.005. Epub 2005 Jul 5.

DOI:10.1016/j.anaerobe.2005.04.005
PMID:16701592
Abstract

Tinidazole, a 5-nitroimidazole similar to metronidazole, was studied against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates. The geometric mean MICs of tinidazole and metronidazole were, respectively: C. difficile, 0.31 and 0.28 microg/mL; P. bivia, 2.33 and 1.52 microg/mL; B. fragilis, 0.5 and 0.71 microg/mL.

摘要

替硝唑是一种与甲硝唑类似的5-硝基咪唑，对40株艰难梭菌、10株二路普雷沃菌和11株脆弱拟杆菌临床分离株进行了研究。替硝唑和甲硝唑的几何平均最低抑菌浓度分别为：艰难梭菌，0.31和0.28微克/毫升；二路普雷沃菌，2.33和1.52微克/毫升；脆弱拟杆菌，0.5和0.71微克/毫升。

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