Brandi Maria Luisa, Bandinelli Stefania, Iantomasi Teresa, Giusti Francesca, Talluri Eleonora, Sini Giovanna, Nannipieri Fabrizio, Battaglia Santina, Giusti Riccardo, Egan Colin Gerard, Ferrucci Luigi
Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy.
Fondazione Italiana Ricerca sulle Malattie dell'Osso (FIRMO Onlus), Florence, Italy.
Endocr Connect. 2022 Mar 16;11(3):e210571. doi: 10.1530/EC-21-0571.
This study aimed to evaluate the association between the endocrine-disrupting chemical, bisphenol A (BPA) on circulating levels of 25-hydroxy vitamin D (25(OD)D) and other vitamin D metabolites in an elderly population in Italy.
This was a retrospective analysis of the InCHIANTI Biobank in Italy. The association between vitamin D metabolites namely 1,25(OH)D, 25(OH)D, parathyroid hormone (PTH) and BPA levels were evaluated. Multiple regression models were used to examine the association between predictor variables with 1,25(OH)D or 25(OH)D levels.
Samples from 299 individuals aged 72.8 ± 15.7 years were examined. Mean levels of BPA, 1,25(OH)D and 25(OH)D were 351.2 ± 511.6 ng/dL, 43.7 ± 16.9 pg/mL and 20.2 ± 12.1 ng/mL, respectively. One hundred eighty individuals (60.2%) were deficient (<20 ng/mL) in 25(OH)D and this population also presented higher BPA levels (527.9 ± 1289.5 ng/dL vs 86.9 ± 116.8 ng/dL, P < 0.0001). Univariate analysis revealed that BPA levels were negatively correlated with both 1,25(OH)D (r= -0.67, P < 0.0001) and 25(OH)D (r= -0.69, P < 0.0001). Multivariate regression revealed that PTH (β: -0.23, 95% CI: -0.34, -0.13, P < 0.0001) and BPA (β: -0.25, 95% CI: -0.3, -0.19, P < 0.0001) remained significantly associated with 25(OH)D levels while BPA was also associated with 1,25(OH)D levels (β: -0.19, 95% CI: -0.22, -0.15, P < 0.0001). Receiver operating characteristic curve analysis showed that a BPA concentration of >113 ng/dL was the best cut-off to predict individuals deficient in 25(OH)D (area under the curve: 0.87, 95% CI: 0.82-0.90, P < 0.0001).
The strong negative association between BPA and vitamin D in this elderly population warrants further investigation, particularly since this population is already at greatest risk of hypovitaminosis and fracture.
本研究旨在评估环境内分泌干扰化学物质双酚A（BPA）与意大利老年人群循环中25-羟基维生素D（25(OH)D）及其他维生素D代谢物水平之间的关联。
这是一项对意大利InCHIANTI生物样本库的回顾性分析。评估了维生素D代谢物，即1,25(OH)D、25(OH)D、甲状旁腺激素（PTH）与BPA水平之间的关联。使用多元回归模型来检验预测变量与1,25(OH)D或25(OH)D水平之间的关联。
对299名年龄为72.8±15.7岁的个体样本进行了检测。BPA、1,25(OH)D和25(OH)D的平均水平分别为351.2±511.6 ng/dL、43.7±16.9 pg/mL和20.2±12.1 ng/mL。180名个体（60.2%）的25(OH)D水平不足（<20 ng/mL），且该人群的BPA水平也更高（527.9±1289.5 ng/dL对86.9±116.8 ng/dL，P<0.0001）。单因素分析显示，BPA水平与1,25(OH)D（r = -0.67，P<0.0001）和25(OH)D（r = -0.69，P<0.0001）均呈负相关。多因素回归显示，PTH（β：-0.23，95%CI：-0.34，-0.13，P<0.0001）和BPA（β：-0.25，95%CI：-0.3，-0.19，P<0.0001）与25(OH)D水平仍显著相关，而BPA也与1,25(OH)D水平相关（β：-0.19，95%CI：-0.22，-0.15，P<0.0001）。受试者工作特征曲线分析表明，BPA浓度>113 ng/dL是预测25(OH)D缺乏个体的最佳截断值（曲线下面积：0.87，95%CI：0.82 - 0.90，P<0.0001）。
该老年人群中BPA与维生素D之间的强负相关关系值得进一步研究，特别是鉴于该人群已经处于维生素缺乏和骨折风险最高的状态。
