Pinheiro Antonio Luiz B, Gerbi Marleny Elizabeth M M
Laser Center, School of Dentistry, Department of Propedêutica and Clínica Integrada, Universidade Federal da Bahia, Canela Salvador, BA, Salvador, Brazil.
Photomed Laser Surg. 2006 Apr;24(2):169-78. doi: 10.1089/pho.2006.24.169.
This paper aims to report the state of the art with respect to photoengineering of bone repair using laser therapy.
Laser therapy has been reported as an important tool to positively stimulate bone both in vivo and in vitro. These results indicate that photophysical and photochemical properties of some wavelengths are primarily responsible for the tissue responses. The use of correct and appropriate parameters has been shown to be effective in the promotion of a positive biomodulative effect in healing bone.
A series of papers reporting the effects of laser therapy on bone cells and tissue are presented, and new and promising protocols developed by our group are presented.
The results of our studies and others indicate that bone irradiated mostly with infrared (IR) wavelengths shows increased osteoblastic proliferation, collagen deposition, and bone neorformation when compared to nonirradiated bone. Further, the effect of laser therapy is more effective if the treatment is carried out at early stages when high cellular proliferation occurs. Vascular responses to laser therapy were also suggested as one of the possible mechanisms responsible for the positive clinical results observed following laser therapy. It still remains uncertain if bone stimulation by laser light is a general effect or if the isolate stimulation of osteoblasts is possible.
It is possible that the laser therapy effect on bone regeneration depends not only on the total dose of irradiation, but also on the irradiation time and the irradiation mode. The threshold parameter energy density and intensity are biologically independent of one another. This independence accounts for the success and the failure of laser therapy achieved at low-energy density levels.
本文旨在报告关于使用激光疗法进行骨修复光工程的最新技术水平。
激光疗法已被报道为在体内和体外积极刺激骨骼的重要工具。这些结果表明，某些波长的光物理和光化学特性是组织反应的主要原因。已证明使用正确且合适的参数可有效促进愈合骨骼中的积极生物调节作用。
展示了一系列报告激光疗法对骨细胞和组织影响的论文，并介绍了我们团队开发的新的且有前景的方案。
我们的研究及其他研究结果表明，与未照射的骨骼相比，主要用红外（IR）波长照射的骨骼显示出成骨细胞增殖增加、胶原蛋白沉积增加和骨新生。此外，如果在细胞增殖旺盛的早期阶段进行治疗，激光疗法的效果更显著。激光疗法引起的血管反应也被认为是激光疗法后观察到的积极临床结果的可能机制之一。激光对骨骼的刺激是一种普遍效应还是仅能单独刺激成骨细胞仍不确定。
激光疗法对骨再生的影响可能不仅取决于总照射剂量，还取决于照射时间和照射方式。阈值参数能量密度和强度在生物学上相互独立。这种独立性解释了在低能量密度水平下激光疗法的成功与失败。
