Sadeghian Ali, Rohani Bita, Salehi-Marzijarani Mohammad, Fekrazad Reza
Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Lasers Med Sci. 2025 Jan 20;40(1):23. doi: 10.1007/s10103-024-04244-3.
Bone regeneration is a complex process influenced by inflammation and pathological conditions. Efforts to enhance this process include chemical and physical interventions, with PBMT therapy showing promise in improving bone regeneration. Despite conflicting findings in existing literature, this review aims to synthesize clinical evidence on using therapy (PBMT) in bone regeneration and explore its potential clinical applications. A systematic search was performed on electronic databases such as Web of Science, Scopus, and PubMed from the beginning until May 2024 for randomized clinical trials that reported the result of PBMT on bone regeneration. The search strategy involved using a mix of relevant medical subject headings (MeSH) terms and pertinent keywords such as photobiomodulation therapy, low-level laser therapy, bone, regeneration, PBMT, and LLLT. From an initial search identifying 1920 articles, this review centered on 13 articles for analysis, predominantly utilizing radiographical or cone-beam computed tomography (CBCT) assessments. Among these, 7 studies indicated that photobiomodulation therapy (PBMT) did not have a significant impact on bone regeneration. Conversely, 4 studies showed a substantial enhancement in bone density and regeneration with PBMT. Furthermore, 2 studies investigated the impact of varying laser characteristics on case and control groups, concluding no significant difference. In spite of the conflicting results from studies mentioned above, it appears that photobiomodulation has shown positive effects on bone reconstruction. However, further research is necessary to optimize the selection of physical parameters of laser such as wavelength, energy density, and power, as they are crucial for optimizing the effectiveness of photobiomodulation for clinical use.
骨再生是一个受炎症和病理状况影响的复杂过程。增强这一过程的努力包括化学和物理干预措施，其中光生物调节疗法（PBMT）在改善骨再生方面显示出前景。尽管现有文献中的研究结果相互矛盾，但本综述旨在综合关于在骨再生中使用该疗法（PBMT）的临床证据，并探索其潜在的临床应用。从开始到2024年5月，对科学网、Scopus和PubMed等电子数据库进行了系统检索，以查找报告PBMT对骨再生结果的随机临床试验。检索策略包括使用相关医学主题词（MeSH）术语和相关关键词的组合，如光生物调节疗法、低强度激光疗法、骨、再生、PBMT和LLLT。从最初检索到的1920篇文章中，本综述聚焦于13篇文章进行分析，主要采用影像学或锥形束计算机断层扫描（CBCT）评估。其中，7项研究表明光生物调节疗法（PBMT）对骨再生没有显著影响。相反，4项研究表明PBMT可显著提高骨密度和促进骨再生。此外，2项研究调查了不同激光特性对病例组和对照组的影响，得出无显著差异的结论。尽管上述研究结果相互矛盾，但光生物调节似乎已对骨重建显示出积极作用。然而，有必要进一步研究以优化激光物理参数的选择，如波长、能量密度和功率，因为它们对于优化光生物调节在临床应用中的有效性至关重要。
