La Fontaine Javier, Harkless Lawrence B, Davis Christian E, Allen Marque A, Shireman Paula K
Department of Orthopedics, Podiatry Division, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
J Am Podiatr Med Assoc. 2006 May-Jun;96(3):245-52. doi: 10.7547/0960245.
Microvascular dysfunction is an important component of the pathologic processes that occur in diabetic foot disease. The endothelial abnormalities observed in patients with diabetes mellitus are poorly understood, and evidence suggests that endothelial dysfunction could be involved in the pathogenesis of diabetic macroangiopathy and microangiopathy. With the advent of insulin replacement in the early 1900s and increased efforts toward metabolic control of diabetes, long-term complications of this disease have become apparent. These late-term complications are primarily disorders of the vascular system. This article reviews the process of microvascular dysfunction and how it may relate to the pathogenesis of diabetic foot problems.
微血管功能障碍是糖尿病足病病理过程的一个重要组成部分。糖尿病患者中观察到的内皮异常了解甚少，有证据表明内皮功能障碍可能参与糖尿病大血管病变和微血管病变的发病机制。随着20世纪初胰岛素替代疗法的出现以及对糖尿病代谢控制的更多努力，该疾病的长期并发症已变得明显。这些晚期并发症主要是血管系统疾病。本文综述了微血管功能障碍的过程及其与糖尿病足问题发病机制的可能关系。
