乳腺癌患者血清中的迁移刺激活性。

Migration stimulating activity in serum of breast cancer patients.

作者信息

Picardo M, Schor S L, Grey A M, Howell A, Laidlaw I, Redford J, Schor A M

机构信息

Department of Cell and Structural Biology, University of Manchester, UK.

出版信息

Lancet. 1991 Jan 19;337(8734):130-3. doi: 10.1016/0140-6736(91)90798-t.

DOI:10.1016/0140-6736(91)90798-t

PMID:1670786

Abstract

An assay to measure the ability to stimulate migration of fibroblasts into collagen gel was carried out on serum from treated and untreated breast cancer patients and from healthy controls. Migration stimulating activity was found in the serum of 10 (83%) of 12 untreated breast cancer patients immediately before surgical resection of the primary tumour and in 9 (75%) of them 4 days after resection; in 13 (93%) of 14 patients 1-13 years after tumour resection who had received adjuvant treatment; and in 2 (10%) of 20 healthy women matched for age. The migration stimulating activity in cancer patients' serum was indistinguishable from the migration stimulating factor produced in vitro by fetal and cancer patient skin fibroblasts in its behaviour in various biochemical fractionation procedures. The presence of this activity in the serum of treated breast cancer patients clearly distinguishes it from other oncofetal proteins, which all seem to be produced by tumours.

摘要

对经治疗和未经治疗的乳腺癌患者以及健康对照者的血清进行了一项检测，以测量其刺激成纤维细胞迁移至胶原凝胶中的能力。在12例未经治疗的乳腺癌患者中，有10例（83%）在原发性肿瘤手术切除前即刻的血清中发现了迁移刺激活性，其中9例（75%）在切除后4天的血清中发现了该活性；在14例接受辅助治疗的肿瘤切除术后1 - 13年的患者中，有13例（93%）血清中有该活性；而在20例年龄匹配的健康女性中，只有2例（10%）血清中有该活性。癌症患者血清中的迁移刺激活性在各种生化分级分离程序中的表现，与胎儿和癌症患者皮肤成纤维细胞在体外产生的迁移刺激因子无法区分。经治疗的乳腺癌患者血清中存在这种活性，这使其明显有别于其他癌胚蛋白，其他癌胚蛋白似乎都是由肿瘤产生的。