Toyomaki Atsuhito, Kusumi Ichiro, Matsuyama Testsuaki, Kako Yuki, Ito Koki, Koyama Tsukasa
Department of Psychiatry, Graduate School of Medicine, Hokkaido University N15, W7, Sapporo 060-8638, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):95-9. doi: 10.1016/j.pnpbp.2007.07.020. Epub 2007 Aug 2.
Impairment in mismatch negativity (MMN) potentials is a robust finding in schizophrenia. There are few studies which examined the correlation between MMN deficits and neuropsychological performances. The purpose of this study was to investigate the relationship between deficits of tone duration MMN and various neuropsychological measures in schizophrenic patients (n=23). The results demonstrated a significant correlation between low MMN amplitude and poor performances of executive function in Wisconsin Card Sorting Test, Stroop Test and Trail Making Test. Our finding suggests MMN deficits in schizophrenia predict deficits of executive function and might reflect ongoing functional abnormality of fronto-temporal interaction.
失配负波（MMN）电位受损是精神分裂症的一个可靠发现。很少有研究考察MMN缺陷与神经心理学表现之间的相关性。本研究的目的是调查精神分裂症患者（n = 23）音调持续时间MMN缺陷与各种神经心理学测量之间的关系。结果显示，MMN波幅较低与威斯康星卡片分类测验、斯特鲁普测验和连线测验中执行功能表现较差之间存在显著相关性。我们的发现表明，精神分裂症患者的MMN缺陷预示着执行功能缺陷，可能反映了额颞叶相互作用的持续功能异常。
