Vaccarella Salvatore, Lazcano-Ponce Eduardo, Castro-Garduño José Antonio, Cruz-Valdez Aurelio, Díaz Vicente, Schiavon Rafaela, Hernández Pilar, Kornegay Janet R, Hernández-Avila Mauricio, Franceschi Silvia
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 2006 Oct 15;119(8):1934-9. doi: 10.1002/ijc.21992.
Large studies of genital human papillomavirus (HPV) infection in men are few and mainly include high-risk groups. We interviewed 779 men who requested a vasectomy in 27 public clinics in 14 states of Mexico. Exfoliated cells were obtained from the scrotum, the shaft of the penis, the top of the penis including the coronal sulcus, the glans and the opening of the meatus. HPV testing was performed using biotinylated L1 consensus primers and reverse line blot. Unconditional logistic regression was used to estimate odds ratios (ORs) of being HPV-positive and corresponding 95% confidence intervals (CIs). The prevalence of any type of HPV was 8.7%. HPV positivity was highest among men below age 25 (13.6%), and lowest among men aged 40 years or older (6.0%). The most commonly found HPV types were, in decreasing order, HPV59, 51, 6, 16 and 58. Lifetime number of sexual partners was associated with HPV positivity (OR for > or = 4 vs. 1 partner = 3.7, 95% CI: 2.0-6.8), mainly on account of the strong association with number of occasional and sex-worker partners. Condom use with both regular (OR = 0.4, 95% CI: 0.1-1.0) and sex-worker (OR = 0.1, 95% CI: 0.0-0.3) partners and circumcision (OR = 0.2, 95% CI: 0.1-0.4) were inversely associated with HPV positivity. HPV prevalence in Mexican men was similar to the prevalence found in Mexican women of the same age groups. The association between HPV positivity and lifetime number of sexual partners in the present low-risk male population is one of the strongest ever reported in studies in men. Condom use and circumcision were associated with a strong reduction in HPV prevalence.
针对男性生殖器人乳头瘤病毒（HPV）感染的大型研究较少，且主要集中在高危人群。我们对墨西哥14个州27家公立诊所中要求进行输精管切除术的779名男性进行了访谈。从阴囊、阴茎体、阴茎顶端（包括冠状沟、龟头和尿道口）获取脱落细胞。使用生物素化L1共有引物和反向线印迹法进行HPV检测。采用无条件逻辑回归来估计HPV阳性的比值比（OR）及相应的95%置信区间（CI）。任何类型HPV的患病率为8.7%。25岁以下男性的HPV阳性率最高（13.6%），40岁及以上男性的HPV阳性率最低（6.0%）。最常见的HPV类型依次为HPV59、51、6、16和58。性伴侣的终生数量与HPV阳性相关（性伴侣≥4名与1名相比，OR = 3.7，95%CI：2.0 - 6.8），这主要是因为与偶然伴侣及性工作者伴侣的数量有很强的关联。与固定性伴侣（OR = 0.4，95%CI：0.1 - 1.0）和性工作者伴侣（OR = 0.1，95%CI：0.0 - 0.3）使用避孕套以及包皮环切术（OR = 0.2，9%CI：0.1 - 0.4）与HPV阳性呈负相关。墨西哥男性的HPV患病率与同年龄组墨西哥女性的患病率相似。在当前低风险男性人群中，HPV阳性与性伴侣终生数量之间的关联是男性研究中报道过的最强关联之一。使用避孕套和包皮环切术与HPV患病率的大幅降低相关。
