Zhu Cheng, McEver Rodger P
Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Mol Cell Biomech. 2005 Sep;2(3):91-104.
Force can shorten the lifetimes of receptor-ligand bonds by accelerating their dissociation. Perhaps paradoxical at first glance, bond lifetimes can also be prolonged by force. This counterintuitive behavior was named catch bonds, which is in contrast to the ordinary slip bonds that describe the intuitive behavior of lifetimes being shortened by force. Fifteen years after their theoretical proposal, catch bonds have finally been observed. In this article we review recently published data that have demonstrated catch bonds in the selectin system and suggested catch bonds in other systems, the theoretical models for their explanations, and their function as a mechanism for flow-enhanced adhesion.
力可通过加速受体 - 配体键的解离来缩短其寿命。乍一看可能有些矛盾，力也可延长键的寿命。这种与直觉相悖的行为被称为捕获键，它与普通的滑动键形成对比，普通滑动键描述的是力会缩短寿命的直观行为。在其理论提出十五年后，捕获键终于被观察到了。在本文中，我们回顾了最近发表的数据，这些数据证明了选择素系统中的捕获键，并暗示了其他系统中存在捕获键，还介绍了用于解释它们的理论模型，以及它们作为流量增强黏附机制的功能。
