Chipuk J E, Bouchier-Hayes L, Green D R
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Cell Death Differ. 2006 Aug;13(8):1396-402. doi: 10.1038/sj.cdd.4401963. Epub 2006 May 19.
Mitochondrial outer membrane permeabilization (MOMP) is considered the 'point of no return' as this event is responsible for engaging the apoptotic cascade in numerous cell death pathways. MOMP is directly governed by a subset of the BCL-2 family of proapoptotic proteins, which induce disruptions in the outer mitochondrial membrane (OMM) and subsequent release of death-promoting proteins like cytochrome c. The proposal here is centered on our hypothesis that MOMP is dictated by an interaction between the cytosol and the OMM, and although proteins of the OMM may be important in the process, the 'decision' to undergo apoptosis originates within the cytosol with no participation (in terms of yes, no and when) by mitochondria.
线粒体外膜通透性改变（MOMP）被认为是“不可逆转的点”，因为这一事件在众多细胞死亡途径中引发凋亡级联反应。MOMP直接由促凋亡蛋白BCL-2家族的一个亚群控制，这些蛋白会导致线粒体外膜（OMM）破坏，并随后释放细胞色素c等促死亡蛋白。这里的提议集中于我们的假设，即MOMP由细胞质和OMM之间的相互作用决定，尽管OMM的蛋白在这一过程中可能很重要，但细胞凋亡的“决定”源自细胞质，线粒体不参与（无论是肯定、否定还是何时）这一决定。
