Lopes-Bezerra Leila M, Schubach Armando, Costa Rosane O
Departamento de Biologia Celular e Genética, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, 20550-013 Rio de Janeiro, RJ, Brazil.
An Acad Bras Cienc. 2006 Jun;78(2):293-308. doi: 10.1590/s0001-37652006000200009. Epub 2006 May 11.
For a long time sporotrichosis has been regarded to have a low incidence in Brazil; however, recent studies demonstrate that not only the number of reported cases but also the incidence of more severe or atypical clinical forms of the disease are increasing. Recent data indicate that these more severe forms occur in about 10% of patients with confirmed diagnosis. The less frequent forms, mainly osteoarticular sporotrichosis, might be associated both with patient immunodepression and zoonotic transmission of the disease. The extracutaneous form and the atypical forms are a challenge to a newly developed serological test, introduced as an auxiliary tool for the diagnosis of unusual clinical forms of sporotrichosis.
长期以来,孢子丝菌病在巴西一直被认为发病率较低;然而,最近的研究表明,不仅报告的病例数量在增加,而且该疾病更严重或非典型临床形式的发病率也在上升。最近的数据表明,这些更严重的形式约发生在10%确诊患者中。较少见的形式,主要是骨关节孢子丝菌病,可能与患者免疫抑制及该疾病的人畜共患病传播有关。皮肤外形式和非典型形式对一种新开发的血清学检测构成挑战,该检测被用作诊断孢子丝菌病异常临床形式的辅助工具。