Liu Tao, Kong Weijia, Yang Pingchang, Wang Binquan
Department of Otorhinolaryngology, Unon Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022, China.
J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):63-7. doi: 10.1007/BF02828040.
In order to gain insight into a possible association between chronic sinusitis and asthma, 85 patients with sinusitis and asthma underwent functional endoscopic sinus surgical treatment and serum antibodies and cytokines were measured. The results showed that 51 out of 85 patients with high serum anti Staphylococcus enterotoxin B (SEB) antibody before treatment obtained satisfactory results for both sinusitis and asthma. The high level of Th2 cytokine IL-4 was down regulated to the levels of normal controls after sinus surgery. Thirty-four out of 85 patients did not show high serum anti-SEB antibody before sinus surgery and did not show much improvement in their asthmatic symptoms although sinusitis symptoms were resolved by sinus surgery. It was concluded that bacterial superantigen SEB (in the sinuses) might play a crucial role in the pathogenesis of lower airway hypersensitivity.
为了深入了解慢性鼻窦炎与哮喘之间可能存在的关联，85例患有鼻窦炎和哮喘的患者接受了功能性鼻内镜鼻窦手术治疗，并检测了血清抗体和细胞因子。结果显示，85例患者中，51例术前血清抗B型葡萄球菌肠毒素（SEB）抗体水平较高，鼻窦炎和哮喘均取得了满意的治疗效果。鼻窦手术后，Th2细胞因子IL-4的高水平下调至正常对照水平。85例患者中，34例鼻窦手术前血清抗SEB抗体水平不高，尽管鼻窦炎症状通过鼻窦手术得到缓解，但其哮喘症状改善不明显。研究得出结论，细菌超抗原SEB（鼻窦中）可能在下气道超敏反应的发病机制中起关键作用。
