Temin H M, Kassner V K
J Gen Virol. 1975 Jun;27(3):267-74. doi: 10.1099/0022-1317-27-3-267.
After an initial acute infection with cell killing, chicken or duck embryo fibroblasts infected in culture with reticuloendotheliosis viruses set up a chronic infection with no cell killing or morphological transformation. Essentially all of the chronically infected cells produced virus. The virus production was not sensitive to cytosine arabinoside or mitomycin C as was virus production in an acute infection. The chronically infected cells had a strong group-specific resistancto the c.p.e. of superinfecting reticuloendotheliosis viruses. However, they were sensitive to vesicular stomatitis virus and avian leukosis-sarcoma viruses. After double infection, single cells produced reticuloendotheliosis virus and avian leukosis-sarcoma virus.
在经历了最初伴有细胞杀伤的急性感染后，在培养物中感染网状内皮组织增殖病病毒的鸡胚或鸭胚成纤维细胞建立了一种慢性感染，没有细胞杀伤或形态转化。基本上所有慢性感染的细胞都产生病毒。病毒产生不像急性感染时那样对阿糖胞苷或丝裂霉素C敏感。慢性感染的细胞对超感染的网状内皮组织增殖病病毒的细胞病变效应具有很强的群特异性抗性。然而，它们对水疱性口炎病毒和禽白血病 - 肉瘤病毒敏感。双重感染后，单个细胞产生网状内皮组织增殖病病毒和禽白血病 - 肉瘤病毒。
