Bergamaschi E, Catalani Simona, Folesani Giuseppina, Venco Paola, Bodini Elena, Guidetti F, Bergonzi R, Franchini I, Apostoli P
Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Sezione di Medicina del Lavoro e Tossicologia Industriale, Università degli Studi di Parma.
Med Lav. 2005 Sep-Oct;96(5):390-402.
To assess and classify exposure to Polycyclic Aromatic Hydrocarbons (PAHs) in some specific working areas of a steel foundry operating with a continuous casting process and evaluate biomonitoring data in different job tasks.
Exposure to dusts and six PAHs classified as carcinogenic by EU directives was studied in a cohort of 35 male foundry workers (aged 41.1 +/- 6.9 years), who were examined both prior to and at the end of the work-shift (06:00 a.m.-02:00 p.m.) in two different periods. The urinary excretion of 1-hydroxypyrene (1-OH-P) was measured as a biomarker of exposure to pyrene.
PAHs concentrations ranged from 461.8 to 935.6 ng/m3 near the continuous casting area, whereas lower values were measured near the ladle furnace. End of shift 1-OH-P values were higher in 11 non-smoking workers involved in continuous casting process as compared to those employed in mantenance and furnace areas (median of the second determination: 5.70 microg/g creatinine--range: 1.24-21.24 vs 1.17 microg/g creatinine--range: 0.23-4.49; p< 0.001). 1-OH-P excretion was significantly correlated with both the sum of six carcinogenic PAHs and pyrene airborne concentrations. In two biomonitoring sessions, 9.1% and 34.3% of the workers respectively showed end-of-shift 1-OH-P values exceeding the occupational exposure limit (OEL) (4.4 microg/g creatinine or 2.3 micromol/mol(-1) creatinine) recommended for coke-oven workers.
1-OH-P is a useful biomarker in assessing PAH exposure and is associated with job category at a Steelplant. Due to exposure variability, to assess risk associated with PAHs exposure, biological monitoring should be carried out periodically.
评估并分类一家采用连铸工艺的铸钢厂某些特定工作区域内多环芳烃（PAHs）的暴露情况，并评估不同工作任务中的生物监测数据。
对35名男性铸钢厂工人（年龄41.1±6.9岁）进行了研究，调查他们在两个不同时间段的班前和班末（上午6:00 - 下午2:00）接触粉尘和欧盟指令列为致癌物的六种PAHs的情况。测量尿中1-羟基芘（1-OH-P）的排泄量作为接触芘的生物标志物。
连铸区域附近PAHs浓度范围为461.8至935.6 ng/m3，而在钢包精炼炉附近测得的值较低。参与连铸工艺的11名非吸烟工人班末的1-OH-P值高于维修和熔炉区域的工人（第二次测定中位数：5.70μg/g肌酐 - 范围：1.24 - 21.24 vs 1.17μg/g肌酐 - 范围：0.23 - 4.49；p<0.001）。1-OH-P排泄量与六种致癌PAHs总和及空气中芘浓度均显著相关。在两次生物监测中，分别有9.1%和34.3%的工人班末1-OH-P值超过了焦炉工人推荐的职业接触限值（OEL）（4.4μg/g肌酐或2.3μmol/mol(-1)肌酐）。
1-OH-P是评估PAH暴露的有用生物标志物，且与钢铁厂的工作类别相关。由于暴露的变异性，为评估与PAHs暴露相关的风险，应定期进行生物监测。
