Low Kathy A, Leaver Echo, Kramer Arthur F, Fabiani Monica, Gratton Gabriele
Beckman Institute and Psychology Department, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Psychophysiology. 2006 Mar;43(2):127-36. doi: 10.1111/j.1469-8986.2006.00390.x.
This study used the high spatial and temporal resolution of the event-related optical signal (EROS) to investigate the timing of neuronal activity in frontal cortex during auditory target detection and passive oddball tasks. Activation in right middle frontal gyrus (MFG) peaked approximately 350 ms following rare target tones. This corresponded closely to the latency of the simultaneously recorded electrical P3 component. In addition, we found activation in left lateral MFG peaking at approximately 130 ms following tone onset for conditions that may have required response inhibition. These results correspond with activation patterns observed in similar fMRI studies, but provide temporal tags for the activated locations. These data may help bridge the gap between electrophysiological and hemodynamic measures of target detection and contribute to our understanding of the spatiotemporal dynamics of brain activity during target processing.
本研究利用事件相关光信号（EROS）的高空间和时间分辨率，来研究在听觉目标检测和被动Oddball任务期间额叶皮质神经元活动的时间。在罕见目标音调之后，右侧额中回（MFG）的激活在大约350毫秒时达到峰值。这与同时记录的电P3成分的潜伏期密切对应。此外，我们发现在可能需要反应抑制的条件下，左侧额中回外侧的激活在音调开始后大约130毫秒时达到峰值。这些结果与在类似功能磁共振成像研究中观察到的激活模式一致，但为激活位置提供了时间标记。这些数据可能有助于弥合目标检测的电生理测量和血液动力学测量之间的差距，并有助于我们理解目标处理过程中大脑活动的时空动态。
