Hofer Alex, Siedentopf Christian M, Ischebeck Anja, Rettenbacher Maria A, Verius Michael, Felber Stephan, Wolfgang Fleischhacker W
Department of Biological Psychiatry, Medical University Innsbruck, Austria.
Psychol Med. 2007 Jan;37(1):109-19. doi: 10.1017/S0033291706008919. Epub 2006 Oct 12.
Previous studies have suggested that men and women process emotional stimuli differently. In this study, we used event-related functional magnetic resonance imaging (fMRI) to investigate gender differences in regional cerebral activity during the perception of positive or negative emotions.
The experiment comprised two emotional conditions (positively/negatively valenced words) during which fMRI data were acquired.
Thirty-eight healthy volunteers (19 males, 19 females) were investigated. A direct comparison of brain activation between men and women revealed differential activation in the right putamen, the right superior temporal gyrus, and the left supramarginal gyrus during processing of positively valenced words versus non-words for women versus men. By contrast, during processing of negatively valenced words versus non-words, relatively greater activation was seen in the left perirhinal cortex and hippocampus for women versus men, and in the right supramarginal gyrus for men versus women.
Our findings suggest gender-related neural responses to emotional stimuli and could contribute to the understanding of mechanisms underlying the gender disparity of neuropsychiatric diseases such as mood disorders.
先前的研究表明，男性和女性处理情绪刺激的方式不同。在本研究中，我们使用事件相关功能磁共振成像（fMRI）来研究在感知积极或消极情绪期间大脑区域活动的性别差异。
实验包括两种情绪条件（正价/负价词汇），在此期间采集fMRI数据。
对38名健康志愿者（19名男性，19名女性）进行了研究。男性和女性大脑激活的直接比较显示，在处理正价词汇与非词汇时，女性与男性相比，右侧壳核、右侧颞上回和左侧缘上回有不同的激活。相比之下，在处理负价词汇与非词汇时，女性与男性相比，左侧嗅周皮质和海马相对激活更强，男性与女性相比，右侧缘上回激活更强。
我们的研究结果表明了对情绪刺激的性别相关神经反应，并可能有助于理解诸如情绪障碍等神经精神疾病性别差异背后的机制。
