Subramony J Anand, Sharma Ashutosh, Phipps J B
ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94043, USA.
Int J Pharm. 2006 Jul 6;317(1):1-6. doi: 10.1016/j.ijpharm.2006.03.053. Epub 2006 Apr 18.
Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.
本文综述了经离子电渗疗法的透皮给药，特别关注用于局部麻醉的利多卡因和用于患者自控急性治疗（如术后疼痛）的芬太尼的给药。重点介绍了微处理器控制器在实现剂量测定、交替/反向极性、预编程和基于传感器的给药方面的作用。简要描述了离子电渗给药中诸如触觉信号、遥测控制和脉动波形等独特特征。
