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本文引用的文献

1
Members of the 30- to 32-kilodalton mycolyl transferase family (Ag85) from culture filtrate of Mycobacterium avium subsp. paratuberculosis are immunodominant Th1-type antigens recognized early upon infection in mice and cattle.来自副结核分枝杆菌培养滤液的30至32千道尔顿分枝菌酸转移酶家族（Ag85）成员是小鼠和牛感染早期识别的免疫显性Th1型抗原。
Infect Immun. 2006 Jan;74(1):202-12. doi: 10.1128/IAI.74.1.202-212.2006.
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Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis.用脂质配方卡介苗口服免疫牛对免疫反应及牛结核病防护的影响。
Vaccine. 2005 May 20;23(27):3581-9. doi: 10.1016/j.vaccine.2005.01.150.
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Improved tuberculosis DNA vaccines by formulation in cationic lipids.通过阳离子脂质制剂改进的结核分枝杆菌DNA疫苗。
Infect Immun. 2002 Jul;70(7):3681-8. doi: 10.1128/IAI.70.7.3681-3688.2002.
4
Mycobacterium avium subsp. paratuberculosis in Veterinary Medicine.兽医医学中的副结核分枝杆菌鸟亚种
Clin Microbiol Rev. 2001 Jul;14(3):489-512. doi: 10.1128/CMR.14.3.489-512.2001.
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Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting.通过蛋白加强免疫提高编码Ag85的结核DNA疫苗的免疫原性和保护效力。
Infect Immun. 2001 May;69(5):3041-7. doi: 10.1128/IAI.69.5.3041-3047.2001.
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Assessment of immunity to mycobacterial infection with luciferase reporter constructs.利用荧光素酶报告基因构建体评估对分枝杆菌感染的免疫力。
Infect Immun. 1999 Sep;67(9):4586-93. doi: 10.1128/IAI.67.9.4586-4593.1999.
7
Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis.开发一种基于萤火虫荧光素酶的检测方法，用于测定副结核分枝杆菌亚种的抗菌药敏性。
J Clin Microbiol. 1999 Feb;37(2):304-9. doi: 10.1128/JCM.37.2.304-309.1999.
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Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections.感染基因组学：Nramp1作为细胞内感染天然抗性的主要决定因素。
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9
Phage infection, transfection and transformation of Mycobacterium avium complex and Mycobacterium paratuberculosis.鸟分枝杆菌复合群和副结核分枝杆菌的噬菌体感染、转染及转化
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用于快速筛选小鼠疫苗候选物的发光副结核分枝杆菌亚种的开发。

Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice.

作者信息

Rosseels Valérie, Roupie Virginie, Zinniel Denise, Barletta Raúl G, Huygen Kris

机构信息

WIV-Pasteur Institute Brussels, 642 Engelandstraat, B-1180 Brussels, Belgium.

出版信息

Infect Immun. 2006 Jun;74(6):3684-6. doi: 10.1128/IAI.01521-05.

DOI:10.1128/IAI.01521-05
PMID:16714604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1479266/
Abstract

Mycobacterium avium subsp. paratuberculosis is a slowly growing mycobacterial species, requiring 6 to 8 weeks of culture before colonies can be counted visually. Here, we describe the development of luminescent M. avium subsp. paratuberculosis expressing luxAB genes of Vibrio harveyi and its use for vaccine testing in an experimental mouse model, replacing fastidious CFU counting by rapid luminometry.

摘要

副结核分枝杆菌鸟亚种是一种生长缓慢的分枝杆菌，需要6至8周的培养时间才能肉眼计数菌落。在此，我们描述了表达哈维氏弧菌luxAB基因的发光副结核分枝杆菌鸟亚种的构建及其在实验小鼠模型中用于疫苗测试的应用，通过快速发光测定法取代了繁琐的菌落形成单位计数。