小鼠卵母细胞中的APCcdh1活性可阻止其进入第一次减数分裂。
APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division.
作者信息
Reis Alexandra, Chang Heng-Yu, Levasseur Mark, Jones Keith T
机构信息
Institute for Cell and Molecular Biosciences, The Medical School, Framlington Place, University of Newcastle-upon-Tyne, Newcastle, NE2 4HH, UK.
出版信息
Nat Cell Biol. 2006 May;8(5):539-40. doi: 10.1038/ncb1406.
Abstract
Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APCcdh1 is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APCcdh1 is active in mouse oocytes and is necessary to maintain prophase arrest.
摘要
完全成熟的哺乳动物卵母细胞在卵巢中维持减数分裂前期I生发泡期停滞状态长达很长时间，直至促黄体生成素激增诱导其进入第一次减数分裂。Cdh1是后期促进复合体（APC）的激活因子，而APCcdh1通常局限于细胞周期的M期末期至G1期早期。在此，我们发现APCcdh1在小鼠卵母细胞中具有活性，并且对于维持前期停滞是必需的。
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