Conti Marco, Kunitomi Chisato
Center for Reproductive Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA.
Center for Reproductive Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, and Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143, USA.
Semin Cell Dev Biol. 2024 Feb 15;154(Pt B):88-98. doi: 10.1016/j.semcdb.2023.03.003. Epub 2023 Mar 7.
Transcriptional and post-transcriptional regulations control gene expression in most cells. However, critical transitions during the development of the female gamete relies exclusively on regulation of mRNA translation in the absence of de novo mRNA synthesis. Specific temporal patterns of maternal mRNA translation are essential for the oocyte progression through meiosis, for generation of a haploid gamete ready for fertilization and for embryo development. In this review, we will discuss how mRNAs are translated during oocyte growth and maturation using mostly a genome-wide perspective. This broad view on how translation is regulated reveals multiple divergent translational control mechanisms required to coordinate protein synthesis with progression through the meiotic cell cycle and with development of a totipotent zygote.
转录调控和转录后调控控制着大多数细胞中的基因表达。然而，雌性配子发育过程中的关键转变完全依赖于在没有从头合成mRNA的情况下对mRNA翻译的调控。母体mRNA翻译的特定时间模式对于卵母细胞通过减数分裂的进程、产生准备受精的单倍体配子以及胚胎发育至关重要。在这篇综述中，我们将主要从全基因组的角度讨论卵母细胞生长和成熟过程中mRNA是如何翻译的。这种关于翻译如何被调控的广泛观点揭示了多种不同的翻译控制机制，这些机制是协调蛋白质合成与减数分裂细胞周期进程以及全能合子发育所必需的。
