The antigen recognized by MOMA-I is sialoadhesin.

作者信息

Oetke Cornelia, Kraal Georg, Crocker Paul R

机构信息

The Wellcome Trust Biocentre, Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, UK.

出版信息

Immunol Lett. 2006 Jul 15;106(1):96-8. doi: 10.1016/j.imlet.2006.04.004. Epub 2006 May 8.

The monoclonal antibody MOMA-1 is a widely-used marker for marginal metallophilic macrophages in spleen and some other subsets of macrophages. The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family. Using flow cytometry of Sn-transfected cells and staining of lymphoid tissue sections from Sn-deficient mice, we demonstrate here that the antigen recognized by MOMA-1 is Sn.