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艾森曼格综合征患者的慢性α1受体阻滞剂治疗

Chronic alpha 1 blockade in a patient with Eisenmenger syndrome.

作者信息

Watanabe K, Mori C, Haneda N, Inoue M, Kishida K, Hayashi Y, Ozasa H

机构信息

Department of Pediatrics, Shimane Medical University, Izumo, Japan.

出版信息

Pediatr Cardiol. 1991 Jan;12(1):52-3. doi: 10.1007/BF02238502.

DOI:10.1007/BF02238502
PMID:1671797
Abstract

In an 18-year-old male with Eisenmenger syndrome cyanosis and erythrocytosis were increasing. The erythrocytosis diminished following oral bunazosin and phlebotomy was not needed during the treatment. When bunazosin was stopped, the erythrocytosis increased, but when it was resumed, the erythrocytosis and general fatigue diminished.

摘要

一名18岁患有艾森曼格综合征的男性患者，发绀和红细胞增多症逐渐加重。口服布那唑嗪后红细胞增多症减轻，治疗期间无需进行放血治疗。停用布那唑嗪后，红细胞增多症又加重，但重新服用后，红细胞增多症及全身乏力症状减轻。

相似文献

1
Chronic alpha 1 blockade in a patient with Eisenmenger syndrome.艾森曼格综合征患者的慢性α1受体阻滞剂治疗
Pediatr Cardiol. 1991 Jan;12(1):52-3. doi: 10.1007/BF02238502.
2
Renal and hormonal effects of alpha 1-adrenoceptor blockade by bunazosin in essential hypertension.
Eur J Clin Pharmacol. 1989;36(6):575-8. doi: 10.1007/BF00637738.
3
[Acute and chronic effects of bunazosin in patients with congestive heart failure].布那唑嗪对充血性心力衰竭患者的急性和慢性影响
Kokyu To Junkan. 1989 May;37(5):529-33.
4
Insulin sensitivity following treatment with the alpha 1-blocker bunazosin retard and the beta 1-blocker atenolol in hypertensive non-insulin-dependent diabetes mellitus patients.α1受体阻滞剂布那唑嗪和β1受体阻滞剂阿替洛尔治疗高血压非胰岛素依赖型糖尿病患者后的胰岛素敏感性。
J Hypertens. 1996 Dec;14(12):1469-75. doi: 10.1097/00004872-199612000-00014.
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[The effect of bunazosin on hypertension during anesthesia; effectiveness of nasal instillation].布那唑嗪对麻醉期间高血压的影响；滴鼻给药的有效性
Masui. 1988 Oct;37(10):1228-32.
6
[Treatment of essential hypertension with the alpha-1 antagonist bunazosin retard. A multicenter, double-blind, placebo-controlled study].[用缓释α-1拮抗剂布那唑嗪治疗原发性高血压。一项多中心、双盲、安慰剂对照研究]
Arzneimittelforschung. 1994 Jan;44(1):13-6.
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Correlation between the additive effect of bunazosin and the response to latanoprost on intraocular pressure in patients with glaucoma treated with bunazosin as adjunctive therapy to latanoprost.布那唑嗪作为拉坦前列素辅助治疗青光眼患者时，布那唑嗪的相加作用与拉坦前列素降眼压效果之间的相关性。
Jpn J Ophthalmol. 2006 Jan-Feb;50(1):65-7. doi: 10.1007/s10384-005-0257-1.
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[Clinical efficacy of oxendolene (antiandrogen) and bunazosin hydrochloride (alpha-adrenergic blocker) in the treatment of prostatism--comparative study of oxendolone, bunazocin hydrochloride and their combination].氧雄龙（抗雄激素）与盐酸布那唑嗪（α-肾上腺素能阻滞剂）治疗前列腺增生症的临床疗效——氧雄龙、盐酸布那唑嗪及其联合用药的对比研究
Hinyokika Kiyo. 1987 Nov;33(11):1921-41.
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Therapeutic methods used in patients with Eisenmenger syndrome.艾森曼格综合征患者的治疗方法。
Cardiol J. 2009;16(6):500-6.
10
Bunazosin. Andante, Detantol, E 1015, E 643, EA 0643.布那唑嗪。安坦特、地坦多、E 1015、E 643、EA 0643。
Drugs R D. 1999 Dec;2(6):417-9. doi: 10.2165/00126839-199902060-00013.

本文引用的文献

1
Noninvasive evaluation of pulmonary hypertension by a pulsed Doppler technique.应用脉冲多普勒技术对肺动脉高压进行无创评估。
Circulation. 1983 Aug;68(2):302-9. doi: 10.1161/01.cir.68.2.302.
2
Clinical and echocardiographic evidence suggesting afterload reduction as a mechanism of action of tolazoline in neonatal hypoxemia.临床和超声心动图证据表明，后负荷降低是妥拉唑啉治疗新生儿低氧血症的作用机制。
Pediatr Cardiol. 1984 Apr-Jun;5(2):93-9. doi: 10.1007/BF02424957.
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Alpha blockade in pulmonary hypertension.肺动脉高压中的α受体阻滞剂
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4
[Acute effect of a new alpha 1-receptor blocking drug, E-643, on severe congestive heart failure--pharmacokinetic and hemodynamic studies].[新型α1受体阻断药物E-643对严重充血性心力衰竭的急性作用——药代动力学和血流动力学研究]
Kokyu To Junkan. 1983 Oct;31(10):1117-21.
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Inotropic, vascular and neuroendocrine effects of nifedipine in heart failure: comparison with nitroprusside.硝苯地平在心力衰竭中的变力性、血管及神经内分泌作用：与硝普钠的比较
J Am Coll Cardiol. 1985 Mar;5(3):731-7. doi: 10.1016/s0735-1097(85)80402-2.
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7
Relationship between age, body size, gender, and blood pressure and Doppler flow measurements in the aorta and pulmonary artery.年龄、体型、性别与主动脉和肺动脉血压及多普勒血流测量之间的关系。
Am Heart J. 1987 Jan;113(1):101-9. doi: 10.1016/0002-8703(87)90016-0.
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Vasodilator therapy for primary pulmonary hypertension. Limitations and hazards.
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