Mendez-Sanchez Nahum, Ponciano-Rodriguez Guadalupe, Bermejo-Martinez Luisa, Villa Antonio-R, Chavez-Tapia Norberto-C, Zamora-Valdes Daniel, Pichardo-Bahena Raul, Barredo-Prieto Blanca, Uribe-Ramos Martha-H, Ramos Martha-H, Baptista-Gonzalez Hector A, Uribe Misael
Liver Unit, Biomedical Research Department, Medica Sur Clinic and Foundation, Mexico City, Mexico.
World J Gastroenterol. 2006 May 21;12(19):3096-100. doi: 10.3748/wjg.v12.i19.3096.
To explore the role of ghrelin in gallstone disease.
We carried out a cross-sectional study in 150 subjects, 38 with gallstones (cases) and 112 controls. We also did a real-time PCR-RT study in twenty gallbladder samples each. Body mass index (BMI), serum insulin, ghrelin, and serum lipids were measured. Logistic regression analyses (univariate and multivariate) were conducted to estimate the probability of gallstone disease associated with serum ghrelin concentrations.
Cases were statistically different from controls in gender distribution (P = 0.01), age (53 vs 44 yr, P = 0.002), BMI (28 vs 25; P = 0.004), and glucose (5.26 vs 4.98 mmol/L; P = 0.05). The prevalence of ghrelin serum levels above the third tercile was lower in subjects without metabolic syndrome (P < 0.05). In a multivariate model, we found a protective effect, when ghrelin values were higher than the median value (OR = 0.27, 95%CI 0.09-0.82, P = 0.02). Twenty (20%) gallbladder specimens expressed ghrelin mRNA.
Serum ghrelin concentrations are associated with a protective effect of GD.
探讨胃饥饿素在胆结石疾病中的作用。
我们对150名受试者进行了一项横断面研究，其中38例患有胆结石（病例组），112例为对照组。我们还对每组20个胆囊样本进行了实时逆转录聚合酶链反应（RT-PCR）研究。测量了体重指数（BMI）、血清胰岛素、胃饥饿素和血脂。进行单因素和多因素逻辑回归分析，以评估与血清胃饥饿素浓度相关的胆结石疾病发生概率。
病例组与对照组在性别分布（P = 0.01）、年龄（53岁对44岁，P = 0.002）、BMI（28对25；P = 0.004）和血糖（5.26对4.98 mmol/L；P = 0.05）方面存在统计学差异。在无代谢综合征的受试者中，血清胃饥饿素水平高于第三个三分位数的患病率较低（P < 0.05）。在多因素模型中，我们发现当胃饥饿素值高于中位数时具有保护作用（OR = 0.27，95%CI 0.09 - 0.82，P = 0.02）。20个（20%）胆囊标本表达胃饥饿素mRNA。
血清胃饥饿素浓度与胆结石疾病的保护作用相关。
