Mavrodi Dmitri V, Blankenfeldt Wulf, Thomashow Linda S
Department of Plant Pathology, Washington State University, Pullman, Washington 99164-6430, USA.
Annu Rev Phytopathol. 2006;44:417-45. doi: 10.1146/annurev.phyto.44.013106.145710.
The phenazines include upward of 50 pigmented, heterocyclic nitrogen-containing secondary metabolites synthesized by some strains of fluorescent Pseudomonas spp. and a few other bacterial genera. The antibiotic properties of these compounds have been known for over 150 years, but advances within the past two decades have provided significant new insights into the genetics, biochemistry, and regulation of phenazine synthesis, as well as the mode of action and functional roles of these compounds in the environment. This new knowledge reveals conservation of biosynthetic enzymes across genera but raises questions about conserved biosynthetic mechanisms, and sets the stage for improving the performance of phenazine producers used as biological control agents for soilborne plant pathogens.
吩嗪类化合物包括50多种由荧光假单胞菌属的一些菌株以及其他一些细菌属合成的有色素的含氮杂环次生代谢产物。这些化合物的抗菌特性已为人所知超过150年，但过去二十年的进展为吩嗪合成的遗传学、生物化学和调控，以及这些化合物在环境中的作用方式和功能作用提供了重要的新见解。这一新知识揭示了不同属间生物合成酶的保守性，但也引发了关于保守生物合成机制的问题，并为提高用作土壤传播植物病原体生物防治剂的吩嗪产生菌的性能奠定了基础。
