McDaniel William W, Spiegel David R, Sahota Anupinder K
Department of Psychiatry, Eastern Virginia Medical School, 825 Fairfax Ave., #710, Norfolk, 23507, USA.
J Neuropsychiatry Clin Neurosci. 2006 Spring;18(2):234-8. doi: 10.1176/jnp.2006.18.2.234.
The authors describe four cases of catatonia in which topiramate treatment was used. Commonly effective therapies, including benzodiazepines and divalproex, were proven refractory. In all four cases, subjects experienced complete remission of catatonic symptoms and tolerated treatment well. In one case, all psychotropic medications were discontinued because the patient became delirious. The delirium resolved after discovery and treatment of a urinary tract infection. Catatonic agitation relapsed when topiramate was withdrawn but remitted again when topiramate and lorazepam therapy was restored. In two cases, continued topiramate therapy was accompanied by sustained remission. These case reports present a novel approach to the treatment of catatonia.
作者描述了4例使用托吡酯治疗紧张症的病例。包括苯二氮䓬类药物和丙戊酸在内的常用有效疗法均被证明无效。在所有4例病例中，患者的紧张症症状完全缓解，且对治疗耐受性良好。在1例病例中，由于患者出现谵妄，所有精神药物均被停用。在发现并治疗尿路感染后，谵妄症状得以缓解。停用托吡酯后，紧张性激越症状复发，但恢复托吡酯和劳拉西泮治疗后症状再次缓解。在2例病例中，持续使用托吡酯治疗伴随症状持续缓解。这些病例报告提出了一种治疗紧张症的新方法。
