c-erbB-2在原发性乳腺癌中的长期预后意义。
The long term prognostic significance of c-erbB-2 in primary breast cancer.
作者信息
Winstanley J, Cooke T, Murray G D, Platt-Higgins A, George W D, Holt S, Myskov M, Spedding A, Barraclough B R, Rudland P S
机构信息
University Department of Surgery, Liverpool, UK.
出版信息
Br J Cancer. 1991 Mar;63(3):447-50. doi: 10.1038/bjc.1991.103.
Abstract
The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.
摘要
使用21N多克隆抗体免疫组化技术，对1975年至1981年间接受治疗的465例I期和II期乳腺癌患者石蜡包埋组织中的c-erbB-2癌基因表达进行了评估。104例（22%）患者呈现阳性染色。这与任何其他变量均无关联。癌基因的表达与显著较差的生存率相关，且独立于其他肿瘤变量。
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