乳腺癌中c-erbB-2蛋白过表达是有或无淋巴结受累患者的一个风险因素。
c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes.
作者信息
Gullick W J, Love S B, Wright C, Barnes D M, Gusterson B, Harris A L, Altman D G
机构信息
Imperial Cancer Research Fund Molecular Oncology Group, Hammersmith Hospital, London, UK.
出版信息
Br J Cancer. 1991 Mar;63(3):434-8. doi: 10.1038/bjc.1991.100.
Abstract
The c-erbB-2 gene is overexpressed in about 20% of human breast cancers. Four hundred and eighty-three cases previously examined by immunohistochemical staining for c-erbB-2 expression were analysed to assess the risk associated with the elevated protein expression. Oncoprotein expression was correlated with increasing tumour grade but not with oestrogen receptor status, nodal involvement, tumour size or age. There was an increased risk of relapse and death associated with c-erbB-2 expression irrespective of nodal involvement. This marker thus appears to be a significant prognostic factor in the early as well as the late stages of breast cancer.
摘要
c-erbB-2基因在约20%的人类乳腺癌中过度表达。对先前通过免疫组织化学染色检测c-erbB-2表达的483例病例进行分析，以评估与蛋白表达升高相关的风险。癌蛋白表达与肿瘤分级增加相关，但与雌激素受体状态、淋巴结受累情况、肿瘤大小或年龄无关。无论淋巴结是否受累，c-erbB-2表达均与复发和死亡风险增加相关。因此，该标志物似乎是乳腺癌早期和晚期的一个重要预后因素。
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