O'Hearn Thomas M, Sadda Srinivas R, Weiland James D, Maia Mauricio, Margalit Eyal, Humayun Mark S
The Doheny Eye Institute, The Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.
Vision Res. 2006 Oct;46(19):3198-204. doi: 10.1016/j.visres.2006.03.031. Epub 2006 May 24.
Stimulus threshold and response latencies were measured for electrically elicited retinal ganglion cell responses in retina isolated from the eyes of normal and retinal degenerate (rd1) mice. Stimulation of the ganglion cell-side in normal retina yielded a significantly lower mean threshold and shorter latency when compared with stimulation of the photoreceptor side in normal retina. The latency of the ganglion cell-side stimulation in normal retina also proved to be significantly shorter than the latency for stimulation of the ganglion cell side in rd1 retina. Thus both the electrode positioning as well as the health of the retinal tissue play a role in the stimulating current required to elicit a retinal response.
在从正常小鼠和视网膜退化（rd1）小鼠眼睛分离出的视网膜中，测量了电诱发视网膜神经节细胞反应的刺激阈值和反应潜伏期。与正常视网膜中光感受器侧刺激相比，正常视网膜中神经节细胞侧刺激产生的平均阈值显著更低，潜伏期更短。正常视网膜中神经节细胞侧刺激的潜伏期也被证明明显短于rd1视网膜中神经节细胞侧刺激的潜伏期。因此，电极定位以及视网膜组织的健康状况在引发视网膜反应所需的刺激电流中都起作用。
