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1
Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.曲霉和非曲霉霉菌对卡泊芬净的敏感性：抑制葡聚糖合酶并降低培养物中β-D-1,3-葡聚糖水平
Antimicrob Agents Chemother. 2006 Jun;50(6):2214-6. doi: 10.1128/AAC.01610-05.
2
The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the β-1,3-Glucan Synthase Fks1.棘白菌素对烟曲霉的矛盾效应依赖于β-1,3-葡聚糖合酶Fks1的恢复。
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3
The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.培养基的组成会影响烟曲霉的β-1,3-葡聚糖代谢和β-1,3-葡聚糖合成抑制剂的抗真菌活性。
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6
Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.在高于最低抑菌浓度（矛盾效应）的浓度下，念珠菌通过增加细胞壁几丁质而逃避卡泊芬净的抑制作用；卡泊芬净抑制β-1,6-葡聚糖合成的证据。
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Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin.对卡泊芬净敏感性降低的烟曲霉突变体的鉴定
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Aspergillus fumigatus devoid of cell wall β-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors.缺乏细胞壁β-1,3-葡聚糖的烟曲霉仍可存活，大量释放半乳甘露聚糖，并被隔膜形成抑制剂杀死。
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The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro.抗真菌棘白菌素类药物醋酸卡泊芬净在体外可杀死烟曲霉的生长细胞。
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Pyomelanin Synthesis in Inhibits DHN-Melanin Synthesis and Decreases Cell Wall Chitin Content and Thickness.[细菌名称]中的脓性黑色素合成抑制二羟基萘黑色素合成并降低细胞壁几丁质含量和厚度。 （注：原文中“Inhibits DHN-Melanin Synthesis and Decreases Cell Wall Chitin Content and Thickness.”的动作发出者缺失，这里补充了一个[细菌名称]使句子完整，你可根据实际情况修改）
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本文引用的文献

1
Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.棘白菌素靶点Fks1p中的特定取代导致罕见实验室分离株和临床念珠菌属分离株的敏感性降低。
Antimicrob Agents Chemother. 2005 Aug;49(8):3264-73. doi: 10.1128/AAC.49.8.3264-3273.2005.
2
Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus.罕见及新出现的机会性真菌病原体：对白色念珠菌和烟曲霉之外的耐药性的关注。
J Clin Microbiol. 2004 Oct;42(10):4419-31. doi: 10.1128/JCM.42.10.4419-4431.2004.
3
In vitro activity of anidulafungin against selected clinically important mold isolates.阿尼芬净对选定的临床重要霉菌分离株的体外活性。
Antimicrob Agents Chemother. 2004 May;48(5):1912-5. doi: 10.1128/AAC.48.5.1912-1915.2004.
4
Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi.卡泊芬净、伊曲康唑、泊沙康唑、雷夫康唑、伏立康唑和两性霉素B对448株近期丝状真菌临床分离株的活性。
J Clin Microbiol. 2003 Aug;41(8):3623-6. doi: 10.1128/JCM.41.8.3623-3626.2003.
5
A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases.一种基于微量滴定板的（1,3）-β-葡聚糖合酶荧光测定法。
Anal Biochem. 1997 Jun 15;249(1):88-93. doi: 10.1006/abio.1997.2162.
6
Isolation of a gene involved in 1,3-beta-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein.构巢曲霉中参与1,3-β-葡聚糖合成的基因的分离及相应蛋白质的纯化。
J Bacteriol. 1996 Aug;178(15):4381-91. doi: 10.1128/jb.178.15.4381-4391.1996.

曲霉和非曲霉霉菌对卡泊芬净的敏感性：抑制葡聚糖合酶并降低培养物中β-D-1,3-葡聚糖水平

Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.

作者信息

Kahn Jennifer Nielsen, Hsu Ming-Jo, Racine Fred, Giacobbe Robert, Motyl Mary

机构信息

Infectious Disease Research, Merck and Co., Rahway, NJ 07065-0900, USA.

出版信息

Antimicrob Agents Chemother. 2006 Jun;50(6):2214-6. doi: 10.1128/AAC.01610-05.

DOI:10.1128/AAC.01610-05
PMID:16723587
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1479154/
Abstract

Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

摘要

卡泊芬净抑制β-D-1,3-葡聚糖的合成，而β-D-1,3-葡聚糖是念珠菌属和曲霉菌属细胞壁所必需的成分，但它对较罕见霉菌的活性在很大程度上尚未明确。我们证明，卡泊芬净可抑制β-D-1,3-葡聚糖的合成，并降低链格孢属、弯孢属、帚霉属、枝顶孢属、双极霉属和木霉属临床分离株的体外生长。