曲霉和非曲霉霉菌对卡泊芬净的敏感性：抑制葡聚糖合酶并降低培养物中β-D-1,3-葡聚糖水平
Caspofungin susceptibility in Aspergillus and non-Aspergillus molds: inhibition of glucan synthase and reduction of beta-D-1,3 glucan levels in culture.
作者信息
Kahn Jennifer Nielsen, Hsu Ming-Jo, Racine Fred, Giacobbe Robert, Motyl Mary
机构信息
Infectious Disease Research, Merck and Co., Rahway, NJ 07065-0900, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jun;50(6):2214-6. doi: 10.1128/AAC.01610-05.
Abstract
Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.
摘要
卡泊芬净抑制β-D-1,3-葡聚糖的合成，而β-D-1,3-葡聚糖是念珠菌属和曲霉菌属细胞壁所必需的成分，但它对较罕见霉菌的活性在很大程度上尚未明确。我们证明，卡泊芬净可抑制β-D-1,3-葡聚糖的合成，并降低链格孢属、弯孢属、帚霉属、枝顶孢属、双极霉属和木霉属临床分离株的体外生长。
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