在高于最低抑菌浓度（矛盾效应）的浓度下，念珠菌通过增加细胞壁几丁质而逃避卡泊芬净的抑制作用；卡泊芬净抑制β-1,6-葡聚糖合成的证据。
Escape of Candida from caspofungin inhibition at concentrations above the MIC (paradoxical effect) accomplished by increased cell wall chitin; evidence for beta-1,6-glucan synthesis inhibition by caspofungin.
作者信息
Stevens David A, Ichinomiya Masayuki, Koshi Yukako, Horiuchi Hiroyuki
机构信息
Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128-2699, USA.
出版信息
Antimicrob Agents Chemother. 2006 Sep;50(9):3160-1. doi: 10.1128/AAC.00563-06.
Abstract
Concentrations above the MIC of caspofungin allow growth of some Candida isolates. A strain demonstrating paradoxical growth was grown in the presence and absence of caspofungin, and the cell wall content was analyzed. Beta-1,3-glucan declined 81% in the presence of caspofungin, as expected. Beta-1,6-glucan declined 73%. Chitin increased 898%, demonstrating a mechanism for paradoxical growth-a rapid shift in the key polymer.
摘要
卡泊芬净浓度高于最低抑菌浓度时，仍会有一些念珠菌分离株生长。一株表现出反常生长的菌株分别在有和没有卡泊芬净的情况下培养，然后分析其细胞壁成分。正如预期的那样，在卡泊芬净存在的情况下，β-1,3-葡聚糖下降了81%。β-1,6-葡聚糖下降了73%。几丁质增加了898%，这表明了反常生长的一种机制——关键聚合物的快速转变。
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