Lesem M D, Berrettini W H, Kaye W H, Jimerson D C
Department of Psychiatry, Harris County Psychiatric Center, Houston, TX 77021.
Biol Psychiatry. 1991 Feb 1;29(3):244-52. doi: 10.1016/0006-3223(91)91286-z.
Twenty-one patients with anorexia nervosa and 35 normal-weight patients with bulimia underwent a series of CSF studies involving measurement of CSF dynorphin A 1-8 immunoreactivity during hospitalization in an eating-disorder treatment and research program. The control group consisted of 17 healthy volunteers. There were no statistically significant differences in CSF dynorphin A 1-8 measurements among groups or within a group at various stages of treatment. These results regarding dynorphin A 1-8 immunoreactivity are discussed in light of other evidence for altered opiate function in some eating-disorder patients.
21名神经性厌食症患者和35名体重正常的贪食症患者在一个饮食失调治疗与研究项目住院期间接受了一系列脑脊液研究，包括测量脑脊液中强啡肽A 1-8免疫反应性。对照组由17名健康志愿者组成。在治疗的各个阶段，各组之间或组内脑脊液强啡肽A 1-8测量值均无统计学上的显著差异。根据一些饮食失调患者阿片类功能改变的其他证据，对这些关于强啡肽A 1-8免疫反应性的结果进行了讨论。
