Demitrack M A, Putnam F W, Rubinow D R, Pigott T A, Altemus M, Krahn D D, Gold P W
Department of Psychiatry, University of Michigan, Ann Arbor.
Psychiatry Res. 1993 Oct;49(1):1-10. doi: 10.1016/0165-1781(93)90026-d.
Dissociation is made manifest by a failure to integrate thoughts, feelings, memories, and actions into a unified sense of consciousness. Although dissociation is presumed to be a special state of consciousness manifested by state-dependent memory and physiology, the psychobiology of dissociation is poorly understood. In this study, we examined cerebrospinal fluid levels of the major monoamine metabolites and beta-endorphin in patients with eating disorders (11 with anorexia nervosa, 16 with bulimia nervosa), while they were acutely ill. Dissociative capacity was measured using the Dissociative Experiences Scale (DES). We provide evidence that neurochemical changes in dopaminergic, serotonergic, and opioid systems may be associated with the clinical expression of dissociation in patients with eating disorders during the acute phase of their illness. These preliminary results are compatible with previous studies of neurochemical disturbances in the eating disorders and suggest that future work in dissociation should specifically include examination of these neurobiologic systems.
分离表现为无法将思想、情感、记忆和行为整合为统一的意识感。尽管分离被认为是一种由状态依赖记忆和生理表现出的特殊意识状态，但分离的心理生物学机制仍知之甚少。在本研究中，我们检测了饮食失调患者（11例神经性厌食症患者，16例神经性贪食症患者）急性期脑脊液中主要单胺代谢产物和β-内啡肽的水平。使用分离体验量表（DES）测量分离能力。我们提供的证据表明，多巴胺能、血清素能和阿片类系统的神经化学变化可能与饮食失调患者急性期分离的临床表达有关。这些初步结果与先前关于饮食失调中神经化学紊乱的研究一致，并表明未来关于分离的研究应特别包括对这些神经生物学系统的检查。
