Chen Mao, Fan Zhong-Cai, Liu Xiao-Jing, Deng Jue-Lin, Zhang Li, Rao Li, Yang Qing, Huang De-Jia
Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
Cell Biol Int. 2006 Jul;30(7):576-82. doi: 10.1016/j.cellbi.2006.03.002. Epub 2006 Mar 22.
To investigate whether stem cell transplantation affects ventricular electrophysiology in vivo, either autologous bone marrow mesenchymal stem cells or skeletal myoblast cells were transplanted via a catheter into a doxorubicin-treated failing heart. Four weeks after transplantation, electrophysiological investigation showed that transplantation of either cell type prolonged the local activation time and increased the activation time dispersion. In the stem cell transplantation groups, a positive correlation was demonstrated between activation time dispersion and the number of stem cell-derived cells in the pacing site. It is concluded that transplantation of either mesenchymal stem cells or skeletal myoblast cells might exacerbate abnormalities of local ventricular conduction in the doxorubicin-treated failing heart.
为研究干细胞移植是否会在体内影响心室电生理，将自体骨髓间充质干细胞或骨骼肌成肌细胞通过导管移植到经阿霉素处理的衰竭心脏中。移植后四周，电生理研究显示，两种细胞类型的移植均延长了局部激活时间并增加了激活时间离散度。在干细胞移植组中，起搏部位的激活时间离散度与干细胞衍生细胞数量之间呈正相关。得出的结论是，间充质干细胞或骨骼肌成肌细胞的移植可能会加剧经阿霉素处理的衰竭心脏中局部心室传导的异常。
