一株与猪轮状病毒株密切相关的人轮状病毒的VP1、VP2和VP3基因片段的特征分析
Characterization of VP1, VP2 and VP3 gene segments of a human rotavirus closely related to porcine strains.
作者信息
Varghese Vici, Ghosh Souvik, Das Soma, Bhattacharya Sujit Kumar, Krishnan Triveni, Karmakar Parimal, Kobayashi Nobumichi, Naik Trailokya Nath
机构信息
Division of Virology, National Institute of Cholera and Enteric Diseases, C.I.T. Road, Scheme XM, Beliaghata, P-33, 700010, Kolkata, India.
出版信息
Virus Genes. 2006 Jun;32(3):241-7. doi: 10.1007/s11262-005-6908-y.
Long RNA electropherotype rotavirus strains with subgroup I specificity predominated the infantile gastroenteritis outbreak in Manipur, India, in 1987-88. One such strain (RMC321) was found to possess porcine characteristics in 7 out of 8 genes sequenced. Partial characterization of its remaining VP1, VP2 and VP3 genes along with a porcine rotavirus strain (HP140) uncovered their close genetic relation to porcine strains. VP7 was the only gene segment of this strain with significant genetic identity to human strains. This indicates that a rotavirus reassortant strain with most of its genetic material derived from a porcine strain may cause symptomatic infection in a human host.
具有I亚组特异性的长RNA电泳型轮状病毒株在1987 - 1988年印度曼尼普尔邦的婴儿肠胃炎暴发中占主导地位。发现其中一个这样的毒株（RMC321）在测序的8个基因中有7个具有猪的特征。对其剩余的VP1、VP2和VP3基因以及一株猪轮状病毒株（HP140）进行的部分特征分析发现，它们与猪毒株有密切的遗传关系。VP7是该毒株中唯一与人类毒株有显著遗传同源性的基因片段。这表明，一种大部分遗传物质来源于猪毒株的轮状病毒重配毒株可能会在人类宿主中引起有症状的感染。
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