Nakagami Hironori, Morishita Ryuichi, Maeda Kazuhisa, Kikuchi Yasushi, Ogihara Toshio, Kaneda Yasufumi
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita 565-0871, Osaka, Japan.
J Atheroscler Thromb. 2006 Apr;13(2):77-81. doi: 10.5551/jat.13.77.
Adult stem cells hold great promise for use in tissue repair and regeneration, and the delivery of autologous progenitor cells into ischemic tissue is emerging as a novel therapeutic option. We and others have recently demonstrated the potential impact of adipose tissue-derived stromal cells (ADSC) on regenerative cell therapy for ischemic diseases. The main benefit of ADSC is that they can be easily harvested from patients by a simple, minimally invasive method and also easily cultured. Cultured ADSC can be induced to differentiate into not only adipocytes, but also bone, neurons or endothelial cells in certain conditions. Interestingly, they secrete a number of angiogenesis-related cytokines, such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), which might be suitable for regenerative cell therapy for ischemic diseases. In the ischemic mouse hindlimb, the angiogenic score was improved in the ADSC-treated group. Moreover, recent reports demonstrated that these ADSC can also be induced to differentiate into cardiac myocytes. These adipose tissue-derived cells have potential in angiogenic cell therapy for ischemic disease, and might be applied for regenerative cell therapy instead of bone marrow cells in the near future.
成体干细胞在组织修复和再生方面具有巨大的应用前景，将自体祖细胞输送到缺血组织正成为一种新的治疗选择。我们和其他研究人员最近证明了脂肪组织来源的基质细胞（ADSC）对缺血性疾病再生细胞治疗的潜在影响。ADSC的主要优势在于，可以通过简单的微创方法轻松地从患者体内获取，并且易于培养。培养后的ADSC在特定条件下不仅可以诱导分化为脂肪细胞，还能分化为骨细胞、神经元或内皮细胞。有趣的是，它们会分泌多种与血管生成相关的细胞因子，如血管内皮生长因子（VEGF）和肝细胞生长因子（HGF），这可能适用于缺血性疾病的再生细胞治疗。在缺血小鼠后肢中，ADSC治疗组的血管生成评分有所改善。此外，最近的报告表明，这些ADSC也可以被诱导分化为心肌细胞。这些脂肪组织来源的细胞在缺血性疾病的血管生成细胞治疗中具有潜力，并且在不久的将来可能会替代骨髓细胞应用于再生细胞治疗。
