Lozsadi D A, Larner A J
Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
Dement Geriatr Cogn Disord. 2006;22(2):121-4. doi: 10.1159/000093664. Epub 2006 May 29.
BACKGROUND/AIMS: To investigate the frequency of epilepsy at the time of diagnosis of Alzheimer's disease (AD).
Observational study, Cognitive Function Clinic population, over a 6-year period (2000-2005 inclusive).
In a cohort of 177 patients with newly diagnosed clinically probable AD, 12 (6.8%) had a history of seizure disorder and/or were using anti-epileptic medications at the time of diagnosis. In 6 of these cases (3.4%), seizure onset was approximately concurrent with the onset of cognitive decline, and no symptomatic or provoking factor for seizures other than AD was identified.
Although epileptic seizures are more common later in the course of AD, nonetheless they may accompany the onset of, and be symptomatic of, the disease, perhaps reflecting a shared pathogenesis.
背景/目的：调查阿尔茨海默病（AD）诊断时癫痫的发生率。
观察性研究，认知功能门诊人群，为期6年（包括2000年至2005年）。
在177例新诊断为临床可能AD的患者队列中，12例（6.8%）在诊断时有癫痫发作史和/或正在使用抗癫痫药物。其中6例（3.4%）癫痫发作与认知功能下降大致同时出现，且未发现除AD以外的癫痫症状性或诱发性因素。
虽然癫痫发作在AD病程后期更常见，但它们可能伴随疾病的发作并成为其症状，这或许反映了共同的发病机制。
