Monterrubio Villar Jesús, Córdoba López Alberto, Macayo Sánchez Anselmo J
Intensive Care Unit, Hospital Don Benito-Villanueva, Badajoz, Spain.
Med Sci Monit. 2006 Jun;12(6):CS53-6. Epub 2006 May 29.
Portal vein thrombosis in adults is usually related to cirrhosis. There are several possible therapies. including anticoagulation, transjugular intrahepatic portosystemic shunt, balloon dilatation, local and systemic fibrinolytics agents. Hypercoagulable states are also reported in association with this disease entity. Eosinophilia may activate platelets and promote thrombosis due to proteins contained in intracytoplasmic granules, such as eosinophil cationic protein and major basic protein. There is only one paper in the medical literature linking eosinophilia and portal vein thrombosis.
We present here the case of a middle-age woman with idiopathic eosinophilia and acute portal vein thrombosis with massive venous thrombosis, involving the mesenteric, splenic, inferior cava, iliac and femoral veins, successfully treated with systemic streptokinase.
Acute portal vein thrombosis with associated mesenteric and splenic vein thrombosis is a potentially lethal coagulation disorder that can be treated successfully with systemic streptokinase.
成人门静脉血栓形成通常与肝硬化有关。有几种可能的治疗方法，包括抗凝、经颈静脉肝内门体分流术、球囊扩张、局部和全身纤溶药物。也有报道称高凝状态与该疾病实体相关。嗜酸性粒细胞增多可能会激活血小板并因细胞质颗粒中所含的蛋白质（如嗜酸性粒细胞阳离子蛋白和主要碱性蛋白）而促进血栓形成。医学文献中仅有一篇论文将嗜酸性粒细胞增多与门静脉血栓形成联系起来。
我们在此介绍一名中年女性病例，该患者患有特发性嗜酸性粒细胞增多症和急性门静脉血栓形成，并伴有大量静脉血栓形成，累及肠系膜、脾、下腔、髂和股静脉，经全身链激酶治疗成功。
伴有肠系膜和脾静脉血栓形成的急性门静脉血栓形成是一种潜在致命的凝血障碍，可通过全身链激酶成功治疗。
