Li Wei Bo, Höllriegl Vera, Roth Paul, Oeh Uwe
Institute of Radiation Protection, GSF-National Research Center for Environment and Health, 85764, Neuherberg, Germany.
Radiat Environ Biophys. 2006 Jul;45(2):115-24. doi: 10.1007/s00411-006-0050-7. Epub 2006 May 30.
Intestinal absorption of strontium (Sr) in thirteen healthy adult German volunteers has been investigated by simultaneous oral and intravenous administration of two stable tracer isotopes, i.e. (84)Sr and (86)Sr. The measured Sr tracer concentration in plasma was analyzed using the convolution integral technique to obtain the intestinal absorption rate. The results showed that the Sr labeled in different foodstuffs was absorbed into the body fluids in a large range of difference. The maximum Sr absorption rates were observed within 60-120 min after administration. The rate of absorption is used to evaluate the intestinal absorption fraction, i.e. the f (1) value for various foodstuffs. The equivalent and effective dose coefficients for ingestion of (90)Sr were calculated using these f (1) values, and they were compared with those recommended by the International Commission on Radiological Protection (ICRP). The geometric and arithmetic means of the f (1) values are 0.38 and 0.45 associated with a geometric standard deviation and a standard deviation of 1.88 and 0.22, respectively. The 90% confidence interval of the f (1) values obtained in the present study ranges from 0.13 to 0.98. Expressed as the ratio of the 95 and 50% percentiles of the estimated probability, the uncertainty for the f (1) value corresponds to a factor of 2.58. The effective dose coefficients of (90)Sr after ingestion are 6.1 x 10(-9) Sv Bq(-1) for an f(1) value of 0.05, 1.0 x 10(-8) Sv Bq(-1) for 0.1, 1.9 x 10(-8) Sv Bq(-1) for 0.2, 2.8 x 10(-8) Sv Bq(-1) for 0.3, 3.6 x 10(-8) Sv Bq(-1) for 0.4, 5.3 x 10(-8) Sv Bq(-1) for 0.6, 7.1 x 10(-8) Sv Bq(-1) for 0.8, and 7.9 x 10(-8) Sv Bq(-1) for 0.9, respectively. Taking the effective dose coefficient of 2.8 x 10(-8) Sv Bq(-1) for an f (1) value of 0.3, which is recommended by the ICRP, as a reference, the effective dose coefficient of (90)Sr after ingestion varies by a factor of 2.8 when the f (1) value changes by a factor of 3, i.e. it decreases from 0.3 to 0.1 or increases from 0.3 to 0.9, respectively.
通过同时口服和静脉注射两种稳定的示踪同位素（即⁸⁴Sr和⁸⁶Sr），对13名健康成年德国志愿者肠道对锶（Sr）的吸收情况进行了研究。使用卷积积分技术分析血浆中测得的Sr示踪剂浓度，以获得肠道吸收率。结果表明，不同食物中标记的Sr被吸收进入体液的差异范围很大。给药后60 - 120分钟内观察到最大Sr吸收率。吸收率用于评估肠道吸收分数，即各种食物的f(1)值。使用这些f(1)值计算摄入⁹⁰Sr的当量剂量系数和有效剂量系数，并与国际放射防护委员会（ICRP）推荐的系数进行比较。f(1)值的几何平均值和算术平均值分别为0.38和0.45，几何标准差和标准差分别为1.88和0.22。本研究中获得的f(1)值的90%置信区间为0.13至0.98。以估计概率的95%和50%百分位数之比表示，f(1)值的不确定性对应于2.58的因子。摄入后⁹⁰Sr的有效剂量系数，f(1)值为0.05时为6.1×10⁻⁹Sv Bq⁻¹，0.1时为1.0×10⁻⁸Sv Bq⁻¹，0.2时为1.9×10⁻⁸Sv Bq⁻¹，0.3时为2.8×10⁻⁸Sv Bq⁻¹，0.4时为3.6×10⁻⁸Sv Bq⁻¹，0.6时为5.3×10⁻⁸Sv Bq⁻¹，0.8时为7.1×10⁻⁸Sv Bq⁻¹，0.9时为7.9×10⁻⁸Sv Bq⁻¹。以ICRP推荐的f(1)值为0.3时摄入后⁹⁰Sr的有效剂量系数2.8×10⁻⁸Sv Bq⁻¹为参考，当f(1)值变化3倍（即分别从0.3降至0.1或从0.3升至0.9）时，摄入后⁹⁰Sr的有效剂量系数变化2.8倍。
