Jayalakshmi R, Thirupurasundari C J, Devaraj S Niranjali
Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India.
Mol Cell Biochem. 2006 Nov;292(1-2):59-67. doi: 10.1007/s11010-006-9218-3. Epub 2006 May 30.
Crataegus oxycantha (hawthorn) is used in herbal and homeopathic medicine as a cardiotonic. The present study was done to investigate the effect of the alcoholic extract of Crataegus oxycantha (AEC) on mitochondrial function during experimentally induced myocardial infarction in rat. AEC was administered orally to male albino rats (150-200 g), at a dosage of 0.5 ml/100 g body weight/day, for 30 days. At the end of the experimental period, the animals were administered isoproterenol (85 mg/kg body weight, s.c) for 2 days at an interval of 24 h. After 48 h, the rats were anaesthetized and sacrificed. The hearts were homogenized for biochemical and electron microscopic analysis. AEC pretreatment maintained mitochondrial antioxidant status, prevented mitochondrial lipid peroxidative damage and decrease in Kreb's cycle enzymes induced by isoproterenol in rat heart.
山楂（Crataegus oxycantha）在草药和顺势疗法中用作强心剂。本研究旨在调查山楂醇提取物（AEC）对实验性诱导大鼠心肌梗死期间线粒体功能的影响。将AEC以0.5 ml/100 g体重/天的剂量口服给予雄性白化大鼠（150 - 200 g），持续30天。在实验期结束时，以24小时间隔给动物皮下注射异丙肾上腺素（85 mg/kg体重），持续2天。48小时后，将大鼠麻醉并处死。取心脏进行生化和电子显微镜分析。AEC预处理维持了线粒体抗氧化状态，防止了线粒体脂质过氧化损伤以及异丙肾上腺素诱导的大鼠心脏中三羧酸循环酶的减少。
