Department of Pharmacognosy, Graduate School of Health Sciences, Yeditepe University, Kayisdagi Cad., Atasehir, 34755 Istanbul, Turkey.
Faculty of Pharmacy, Yeditepe University, Kayisdagi Cad., Atasehir, 34755 Istanbul, Turkey.
Molecules. 2023 Sep 8;28(18):6520. doi: 10.3390/molecules28186520.
is a plant endemic to Türkiye. For the first time, this study aimed to comparatively assess its flower-bearing branches, leaves, and fruits with other well-known species (, , and ) in terms of chemical composition and bioactivity studies to evaluate its potential use as a food supplement. Firstly, the contents of total phenolics (TPC), flavonoids (TFC), proanthocyanidin (TPAC), and anthocyanin (TAC) in different plant parts of species were evaluated. The highest TPAC was found in the hydroalcoholic extract of flower-bearing branches. Moreover, all plant parts had comparatively higher amounts of TPC, TFC, and TAC compared to other species. The chemical screening by high-performance thin-layer chromatography (HPTLC) resulted that parts were rich with chlorogenic acid, neochlorogenic acid, quercetin and vitexin derivatives, epicatechin, procyanidin, etc., and their quantities were evaluated by high-performance liquid chromatography (HPLC). In terms of several antioxidant activity outcomes, the flower-bearing branches of showed the highest antioxidant activity by a 2,2-diphenyl-1-picrylhydrazyl (DPPH) test among the assessed antioxidant assays. Additionally, hydroalcoholic extracts of significantly decreased LPS-induced nitric oxide, tumor necrosis factor-alpha, and interleukin-6 production more potently than indomethacin (positive control). In addition to its remarkable anti-inflammatory activity, showed analgesic activity by reducing prostaglandin E levels.
是一种原产于土耳其的植物。本研究首次旨在比较评估其开花枝、叶和果实与其他著名物种（、和）在化学成分和生物活性研究方面的差异，以评估其作为食品补充剂的潜在用途。首先，评估了不同植物部分的总酚（TPC）、类黄酮（TFC）、原花青素（TPAC）和花青素（TAC）含量。在水醇提取物中发现花枝的 TPAC 含量最高。此外，与其他物种相比，所有植物部分的 TPC、TFC 和 TAC 含量都相对较高。高效薄层色谱（HPTLC）的化学筛选表明，各部分富含绿原酸、新绿原酸、槲皮素和牡荆素衍生物、表儿茶素、原花青素等，并用高效液相色谱（HPLC）进行了定量分析。就几种抗氧化活性结果而言，在所评估的抗氧化测定中，开花枝的抗氧化活性最高，DPPH 试验表明其抗氧化活性最高。此外，与阳性对照消炎痛相比，水醇提取物对 LPS 诱导的一氧化氮、肿瘤坏死因子-α和白细胞介素-6 的产生具有更强的抑制作用。除了显著的抗炎活性外，还通过降低前列腺素 E 水平显示出镇痛活性。
