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酰化短缩肽的多组分合成及其对植物病原菌的抗真菌活性。

Multicomponent synthesis of acylated short peptoids with antifungal activity against plant pathogens.

机构信息

Departamento de Química Orgánica and UMYMFOR (CONICET-Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA, Buenos Aires, Argentina.

出版信息

Mol Divers. 2012 Feb;16(1):113-9. doi: 10.1007/s11030-011-9334-1. Epub 2011 Sep 16.

DOI:10.1007/s11030-011-9334-1
PMID:21922290
Abstract

In this article, we describe the synthesis of a small library of short peptoids composed of four glycine residues and acylated with a fatty acid that showed a remarkable in vitro activity against two fungal plant pathogens. Their straightforward synthesis implied two consecutive Ugi reactions and can be efficiently extended to the construction of highly diverse libraries.

摘要

在这篇文章中，我们描述了一种由四个甘氨酸残基组成的短肽类似物的小文库的合成，该文库用脂肪酸酰化，对两种真菌植物病原体表现出显著的体外活性。它们的合成方法简单，涉及两个连续的 Ugi 反应，可以有效地扩展到高度多样化文库的构建。

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