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多组分反应中的选择性：类型与合成应用

Selectivity in multiple multicomponent reactions: types and synthetic applications.

作者信息

Ghashghaei Ouldouz, Seghetti Francesca, Lavilla Rodolfo

机构信息

Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain.

Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Belmeloro, 6, 40126, Bologna, Italy.

出版信息

Beilstein J Org Chem. 2019 Feb 21;15:521-534. doi: 10.3762/bjoc.15.46. eCollection 2019.

DOI:10.3762/bjoc.15.46
PMID:30873236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6404517/
Abstract

Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the case. Selectivity issues then arise, and different scenarios are analyzed. The structural pattern of the reactants, the reaction design and the experimental conditions are the critical factors dictating selectivity in these processes.

摘要

多个多组分反应达到了无与伦比的连接程度，生成高度复杂的加合物。通常，只发生一种涉及同一组反应物的转化类型。然而，在某些情况下并非如此。于是就出现了选择性问题，并对不同情况进行了分析。反应物的结构模式、反应设计和实验条件是决定这些过程中选择性的关键因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/a5ea6dd71a5b/Beilstein_J_Org_Chem-15-521-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/9e4ceac3ffaa/Beilstein_J_Org_Chem-15-521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/698b290b2cac/Beilstein_J_Org_Chem-15-521-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/3da3c22f09ca/Beilstein_J_Org_Chem-15-521-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/602fa94ac2c3/Beilstein_J_Org_Chem-15-521-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/b20d7bc0082a/Beilstein_J_Org_Chem-15-521-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/a5ea6dd71a5b/Beilstein_J_Org_Chem-15-521-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/9e4ceac3ffaa/Beilstein_J_Org_Chem-15-521-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/698b290b2cac/Beilstein_J_Org_Chem-15-521-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/ee81c68e48bb/Beilstein_J_Org_Chem-15-521-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/29509573dad0/Beilstein_J_Org_Chem-15-521-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/8fb0cb4725f4/Beilstein_J_Org_Chem-15-521-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/ec31b8112529/Beilstein_J_Org_Chem-15-521-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/aa71def8deb7/Beilstein_J_Org_Chem-15-521-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/dd65dd478373/Beilstein_J_Org_Chem-15-521-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/c5a5c6e253c6/Beilstein_J_Org_Chem-15-521-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/48c629f255e4/Beilstein_J_Org_Chem-15-521-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/aeed43571bce/Beilstein_J_Org_Chem-15-521-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/3b4a66aa66c5/Beilstein_J_Org_Chem-15-521-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/3da3c22f09ca/Beilstein_J_Org_Chem-15-521-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/602fa94ac2c3/Beilstein_J_Org_Chem-15-521-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/b20d7bc0082a/Beilstein_J_Org_Chem-15-521-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e311/6404517/a5ea6dd71a5b/Beilstein_J_Org_Chem-15-521-g017.jpg

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