多组分反应中的选择性：类型与合成应用

Selectivity in multiple multicomponent reactions: types and synthetic applications.

作者信息

Ghashghaei Ouldouz, Seghetti Francesca, Lavilla Rodolfo

机构信息

Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine (IBUB), University of Barcelona, Av. de Joan XXIII, 27-31, 08028 Barcelona, Spain.

Department of Pharmacy and Biotechnology (FaBiT), University of Bologna, Via Belmeloro, 6, 40126, Bologna, Italy.

出版信息

Beilstein J Org Chem. 2019 Feb 21;15:521-534. doi: 10.3762/bjoc.15.46. eCollection 2019.

Multiple multicomponent reactions reach an unparalleled level of connectivity, leading to highly complex adducts. Usually, only one type of transformation involving the same set of reactants takes place. However, in some occasions this is not the case. Selectivity issues then arise, and different scenarios are analyzed. The structural pattern of the reactants, the reaction design and the experimental conditions are the critical factors dictating selectivity in these processes.