Rarick M U, Loureiro C, Groshen S, Sullivan-Halley J, Gill P S, Bernstein-Singer M, Levine A M
Department of Internal Medicine, University of Southern California School of Medicine, Los Angeles 90033.
J Acquir Immune Defic Syndr (1988). 1991;4(6):593-7.
The pathophysiology of anemia in patients with human immunodeficiency virus (HIV) infection is multifactorial. In order to determine the role of erythropoietin (EPO) response as a cause of the anemia, serum levels were determined by direct radioimmunoassay in 110 symptomatic patients with various stages of HIV infection. Symptomatic patients (ARC and AIDS) not receiving zidovudine (ZDV) therapy demonstrated a strong inverse relationship between serum EPO and hemoglobin levels (p = 0.01 and p less than 0.001, respectively). Patients with AIDS who were anemic while receiving ZDV demonstrated serum EPO levels that ranged from normal to markedly elevated (9-3,390 mU/ml). The diversity of serum EPO levels in patients with HIV infection and anemia suggests that the etiology of anemia in these patients and their potential response to recombinant human EPO may not be uniform.
人类免疫缺陷病毒（HIV）感染患者贫血的病理生理学是多因素的。为了确定促红细胞生成素（EPO）反应作为贫血原因的作用，通过直接放射免疫测定法测定了110例处于不同HIV感染阶段的有症状患者的血清水平。未接受齐多夫定（ZDV）治疗的有症状患者（艾滋病相关综合征和艾滋病）血清EPO与血红蛋白水平之间呈强烈负相关（分别为p = 0.01和p < 0.001）。接受ZDV治疗时贫血的艾滋病患者血清EPO水平范围从正常到显著升高（9 - 3390 mU/ml）。HIV感染和贫血患者血清EPO水平的多样性表明，这些患者贫血的病因及其对重组人促红细胞生成素的潜在反应可能并不一致。
