Zmitek Katja, Zupan Marko, Stavber Stojan, Iskra Jernej
Laboratory of Organic and Bioorganic Chemistry, Jozef Stefan Institute, Jamova 39, Ljubljana, Slovenia.
Org Lett. 2006 Jun 8;8(12):2491-4. doi: 10.1021/ol060590r.
Iodine has been shown to be an efficient catalyst for the selective dihydroperoxidation of ketones with aqueous hydrogen peroxide. Ketones were directly converted to their corresponding gem-dihydroperoxides using a "green" oxidant (30% aq H(2)O(2)) and a simple catalyst (iodine) under neutral conditions in acetonitrile. The yield of hydroperoxidation of various cyclic ketones was 60-98% including androstane-3,17-dione, and acyclic ketones were converted with a similar efficiency. [reaction: see text]
碘已被证明是一种高效催化剂，可用于在过氧化氢水溶液存在下对酮进行选择性二氢过氧化反应。在中性条件下，于乙腈中使用“绿色”氧化剂（30% 过氧化氢水溶液）和简单催化剂（碘），酮可直接转化为相应的偕二氢过氧化物。各种环状酮的氢过氧化产率为60 - 98%，包括雄甾烷 - 3,17 - 二酮，无环酮也能以类似效率进行转化。[反应：见原文]
